D'Andrea L - Search Results

1

Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential.

Bujotzek A, Tiefenthaler G, Lariviere L, D'Andrea L, Marquez EA, Rudloff I, Cho SX, Deen NS, Richter W, Regenass-Lechner F, Poehler A, Whisstock JC, Sydow-Andersen J, Reiser X, Schuster S, Neubauer J, Hoepfl S, Richter K, Nold MF, Nold-Petry CA, Schumacher F, Ellisdon AM. Bujotzek A, et al. Cell Chem Biol. 2022 Apr 21;29(4):586-596.e4. doi: 10.1016/j.chembiol.2021.10.004. Epub 2021 Oct 25. Cell Chem Biol. 2022. PMID: 34699747 Free article.

2

Homodimerization attenuates the anti-inflammatory activity of interleukin-37.

Ellisdon AM, Nold-Petry CA, D'Andrea L, Cho SX, Lao JC, Rudloff I, Ngo D, Lo CY, Soares da Costa TP, Perugini MA, Conroy PJ, Whisstock JC, Nold MF. Ellisdon AM, et al. Sci Immunol. 2017 Feb 10;2(8):eaaj1548. doi: 10.1126/sciimmunol.aaj1548. Sci Immunol. 2017. PMID: 28783685

3

Parsing the IL-37-Mediated Suppression of Inflammasome Function.

Rudloff I, Ung HK, Dowling JK, Mansell A, D'Andrea L, Ellisdon AM, Whisstock JC, Berger PJ, Nold-Petry CA, Nold MF. Rudloff I, et al. Cells. 2020 Jan 10;9(1):178. doi: 10.3390/cells9010178. Cells. 2020. PMID: 31936823 Free PMC article.

4

Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.

D'Andrea L, Lucato CM, Marquez EA, Chang YG, Civciristov S, Mastos C, Lupton CJ, Huang C, Elmlund H, Schittenhelm RB, Mitchell CA, Whisstock JC, Halls ML, Ellisdon AM. D'Andrea L, et al. Sci Signal. 2021 May 4;14(681):eabc4078. doi: 10.1126/scisignal.abc4078. Sci Signal. 2021. PMID: 33947796

5

The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1.

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM. Lupton CJ, et al. Nat Struct Mol Biol. 2021 Dec;28(12):982-988. doi: 10.1038/s41594-021-00687-2. Epub 2021 Dec 9. Nat Struct Mol Biol. 2021. PMID: 34887559

6

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.

Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM. Chang YG, et al. Nat Struct Mol Biol. 2022 Aug;29(8):767-773. doi: 10.1038/s41594-022-00804-9. Epub 2022 Jul 21. Nat Struct Mol Biol. 2022. PMID: 35864164 Free PMC article.

7

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4.

Perry AJ, Wijeyewickrema LC, Wilmann PG, Gunzburg MJ, D'Andrea L, Irving JA, Pang SS, Duncan RC, Wilce JA, Whisstock JC, Pike RN. Perry AJ, et al. J Biol Chem. 2013 May 31;288(22):15821-9. doi: 10.1074/jbc.M113.464545. Epub 2013 Apr 16. J Biol Chem. 2013. PMID: 23592783 Free PMC article.

8

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice.

Santini E, Huynh TN, Longo F, Koo SY, Mojica E, D'Andrea L, Bagni C, Klann E. Santini E, et al. Sci Signal. 2017 Nov 7;10(504):eaan0665. doi: 10.1126/scisignal.aan0665. Sci Signal. 2017. PMID: 29114037 Free PMC article.

9

Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.

Panja D, Kenney JW, D'Andrea L, Zalfa F, Vedeler A, Wibrand K, Fukunaga R, Bagni C, Proud CG, Bramham CR. Panja D, et al. Cell Rep. 2014 Nov 20;9(4):1430-45. doi: 10.1016/j.celrep.2014.10.016. Epub 2014 Nov 6. Cell Rep. 2014. PMID: 25453757 Free article.

10

Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice.

Sabanov V, Braat S, D'Andrea L, Willemsen R, Zeidler S, Rooms L, Bagni C, Kooy RF, Balschun D. Sabanov V, et al. Neuropharmacology. 2017 Apr;116:71-81. doi: 10.1016/j.neuropharm.2016.12.010. Epub 2016 Dec 21. Neuropharmacology. 2017. PMID: 28012946

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