D'Andrea AD - Search Results

1

A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.

Zhou J, Gelot C, Pantelidou C, Li A, Yücel H, Davis RE, Färkkilä A, Kochupurakkal B, Syed A, Shapiro GI, Tainer JA, Blagg BSJ, Ceccaldi R, D'Andrea AD. Zhou J, et al. Nat Cancer. 2021 Jun;2(6):598-610. doi: 10.1038/s43018-021-00203-x. Epub 2021 Jun 17. Nat Cancer. 2021. PMID: 34179826 Free PMC article.

2

The Fanconi anaemia/BRCA pathway.

D'Andrea AD, Grompe M. D'Andrea AD, et al. Nat Rev Cancer. 2003 Jan;3(1):23-34. doi: 10.1038/nrc970. Nat Rev Cancer. 2003. PMID: 12509764 Review.

3

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.

Johnson N, Cai D, Kennedy RD, Pathania S, Arora M, Li YC, D'Andrea AD, Parvin JD, Shapiro GI. Johnson N, et al. Mol Cell. 2009 Aug 14;35(3):327-39. doi: 10.1016/j.molcel.2009.06.036. Mol Cell. 2009. PMID: 19683496 Free PMC article.

4

Targeting DNA repair pathways in AML.

D'Andrea AD. D'Andrea AD. Best Pract Res Clin Haematol. 2010 Dec;23(4):469-73. doi: 10.1016/j.beha.2010.09.005. Epub 2010 Oct 29. Best Pract Res Clin Haematol. 2010. PMID: 21130409 Review.

5

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

Johnson N, Li YC, Walton ZE, Cheng KA, Li D, Rodig SJ, Moreau LA, Unitt C, Bronson RT, Thomas HD, Newell DR, D'Andrea AD, Curtin NJ, Wong KK, Shapiro GI. Johnson N, et al. Nat Med. 2011 Jun 26;17(7):875-82. doi: 10.1038/nm.2377. Nat Med. 2011. PMID: 21706030 Free PMC article.

6

Inhibition of homologous recombination by the PCNA-interacting protein PARI.

Moldovan GL, Dejsuphong D, Petalcorin MI, Hofmann K, Takeda S, Boulton SJ, D'Andrea AD. Moldovan GL, et al. Mol Cell. 2012 Jan 13;45(1):75-86. doi: 10.1016/j.molcel.2011.11.010. Epub 2011 Dec 6. Mol Cell. 2012. PMID: 22153967 Free PMC article.

7

PARI overexpression promotes genomic instability and pancreatic tumorigenesis.

O'Connor KW, Dejsuphong D, Park E, Nicolae CM, Kimmelman AC, D'Andrea AD, Moldovan GL. O'Connor KW, et al. Cancer Res. 2013 Apr 15;73(8):2529-39. doi: 10.1158/0008-5472.CAN-12-3313. Epub 2013 Feb 22. Cancer Res. 2013. PMID: 23436799 Free PMC article.

8

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.

Johnson N, Johnson SF, Yao W, Li YC, Choi YE, Bernhardy AJ, Wang Y, Capelletti M, Sarosiek KA, Moreau LA, Chowdhury D, Wickramanayake A, Harrell MI, Liu JF, D'Andrea AD, Miron A, Swisher EM, Shapiro GI. Johnson N, et al. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17041-6. doi: 10.1073/pnas.1305170110. Epub 2013 Oct 1. Proc Natl Acad Sci U S A. 2013. PMID: 24085845 Free PMC article.

9

Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.

Kim H, Dejsuphong D, Adelmant G, Ceccaldi R, Yang K, Marto JA, D'Andrea AD. Kim H, et al. Mol Cell. 2014 Apr 10;54(1):107-118. doi: 10.1016/j.molcel.2014.02.017. Epub 2014 Mar 20. Mol Cell. 2014. PMID: 24657165 Free PMC article.

10

A unique subset of epithelial ovarian cancers with platinum sensitivity and PARP inhibitor resistance.

Ceccaldi R, O'Connor KW, Mouw KW, Li AY, Matulonis UA, D'Andrea AD, Konstantinopoulos PA. Ceccaldi R, et al. Cancer Res. 2015 Feb 15;75(4):628-34. doi: 10.1158/0008-5472.CAN-14-2593. Epub 2015 Jan 29. Cancer Res. 2015. PMID: 25634215 Free PMC article.

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