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In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
Orofino F, Truglio GI, Fiorucci D, D'Agostino I, Borgini M, Poggialini F, Zamperini C, Dreassi E, Maccari L, Torelli R, Martini C, Bernabei M, Meis JF, Khandelwal NK, Prasad R, Sanguinetti M, Bugli F, Botta M. Orofino F, et al. Int J Antimicrob Agents. 2020 Mar;55(3):105865. doi: 10.1016/j.ijantimicag.2019.105865. Epub 2019 Dec 20. Int J Antimicrob Agents. 2020. PMID: 31866465
Focused library of phenyl-fused macrocyclic amidinoureas as antifungal agents.
Balestri LJI, D'Agostino I, Rango E, Vagaggini C, Marchitiello R, Mariotti M, Casian A, Deodato D, Truglio GI, Orofino F, Sanguinetti M, Bugli F, Botta L, Dreassi E. Balestri LJI, et al. Mol Divers. 2022 Dec;26(6):3399-3409. doi: 10.1007/s11030-022-10388-7. Epub 2022 Feb 10. Mol Divers. 2022. PMID: 35143033 Free PMC article.
Biological investigation of N-methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors.
D'Agostino I, Mathew GE, Angelini P, Venanzoni R, Angeles Flores G, Angeli A, Carradori S, Marinacci B, Menghini L, Abdelgawad MA, Ghoneim MM, Mathew B, Supuran CT. D'Agostino I, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):986-993. doi: 10.1080/14756366.2022.2055009. J Enzyme Inhib Med Chem. 2022. PMID: 35322729 Free PMC article.
Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships.
Fantacuzzi M, D'Agostino I, Carradori S, Liguori F, Carta F, Agamennone M, Angeli A, Sannio F, Docquier JD, Capasso C, Supuran CT. Fantacuzzi M, et al. Among authors: d agostino i. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201402. doi: 10.1080/14756366.2023.2201402. J Enzyme Inhib Med Chem. 2023. PMID: 37073528 Free PMC article.
Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors.
Balestri LJI, Trivisani CI, Orofino F, Fiorucci D, Truglio GI, D'Agostino I, Poggialini F, Botta L, Docquier JD, Dreassi E. Balestri LJI, et al. Among authors: d agostino i. ACS Med Chem Lett. 2023 Mar 21;14(4):417-424. doi: 10.1021/acsmedchemlett.2c00472. eCollection 2023 Apr 13. ACS Med Chem Lett. 2023. PMID: 37077400 Free PMC article.
52 results