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Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis.
Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M. Gómez-Valadés AG, et al. Cell Metab. 2021 Sep 7;33(9):1820-1835.e9. doi: 10.1016/j.cmet.2021.07.008. Epub 2021 Aug 2. Cell Metab. 2021. PMID: 34343501 Free PMC article.
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation.
Costa A, Ai M, Nunn N, Culotta I, Hunter J, Boudjadja MB, Valencia-Torres L, Aviello G, Hodson DJ, Snider BM, Coskun T, Emmerson PJ, Luckman SM, D'Agostino G. Costa A, et al. Mol Metab. 2022 Jan;55:101407. doi: 10.1016/j.molmet.2021.101407. Epub 2021 Nov 26. Mol Metab. 2022. PMID: 34844019 Free PMC article.
Negative energy balance hinders prosocial helping behavior.
Pozo M, Milà-Guasch M, Haddad-Tóvolli R, Boudjadja MB, Chivite I, Toledo M, Gómez-Valadés AG, Eyre E, Ramírez S, Obri A, Ben-Ami Bartal I, D'Agostino G, Costa-Font J, Claret M. Pozo M, et al. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2218142120. doi: 10.1073/pnas.2218142120. Epub 2023 Apr 6. Proc Natl Acad Sci U S A. 2023. PMID: 37023123 Free PMC article.
Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons.
Burke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, Martinez de Morentin PB, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS, Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, Low MJ, Rochford JJ, Myers MG, Evans ML, Heisler LK. Burke LK, et al. Mol Metab. 2016 Jan 22;5(3):245-252. doi: 10.1016/j.molmet.2016.01.005. eCollection 2016 Mar. Mol Metab. 2016. PMID: 26977396 Free PMC article.
Lorcaserin improves glycemic control via a melanocortin neurocircuit.
Burke LK, Ogunnowo-Bada E, Georgescu T, Cristiano C, de Morentin PBM, Valencia Torres L, D'Agostino G, Riches C, Heeley N, Ruan Y, Rubinstein M, Low MJ, Myers MG, Rochford JJ, Evans ML, Heisler LK. Burke LK, et al. Mol Metab. 2017 Oct;6(10):1092-1102. doi: 10.1016/j.molmet.2017.07.004. Epub 2017 Jul 21. Mol Metab. 2017. PMID: 29031711 Free PMC article.
409 results