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Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs.
Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T. Lucas R, et al. Among authors: czikora i. Toxins (Basel). 2013 Jul 15;5(7):1244-60. doi: 10.3390/toxins5071244. Toxins (Basel). 2013. PMID: 23860351 Free PMC article. Review.
Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells.
Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R. Yang G, et al. Among authors: czikora i. Toxins (Basel). 2018 Feb 11;10(2):79. doi: 10.3390/toxins10020079. Toxins (Basel). 2018. PMID: 29439494 Free PMC article.
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. Czikora I, et al. Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32. doi: 10.1164/rccm.201405-0833OC. Am J Respir Crit Care Med. 2014. PMID: 25029038 Free PMC article.
Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.
Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R. Czikora I, et al. Front Immunol. 2017 Jul 21;8:842. doi: 10.3389/fimmu.2017.00842. eCollection 2017. Front Immunol. 2017. PMID: 28785264 Free PMC article.
The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.
Madaio MP, Czikora I, Kvirkvelia N, McMenamin M, Yue Q, Liu T, Toque HA, Sridhar S, Covington K, Alaisami R, O'Connor PM, Caldwell RW, Chen JK, Clauss M, Brands MW, Eaton DC, Romero MJ, Lucas R. Madaio MP, et al. Among authors: czikora i. Kidney Int. 2019 Jun;95(6):1359-1372. doi: 10.1016/j.kint.2018.12.022. Epub 2019 Mar 21. Kidney Int. 2019. PMID: 30905471 Free PMC article.
The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.
Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I. Lucas R, et al. Among authors: czikora i. J Biol Chem. 2016 Nov 4;291(45):23440-23451. doi: 10.1074/jbc.M116.718163. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645999 Free PMC article.
22 results