Czechtizky W - Search Results

1

Molecular optimization by capturing chemist's intuition using deep neural networks.

He J, You H, Sandström E, Nittinger E, Bjerrum EJ, Tyrchan C, Czechtizky W, Engkvist O. He J, et al. Among authors: czechtizky w. J Cheminform. 2021 Mar 20;13(1):26. doi: 10.1186/s13321-021-00497-0. J Cheminform. 2021. PMID: 33743817 Free PMC article.

2

Transformer-based molecular optimization beyond matched molecular pairs.

He J, Nittinger E, Tyrchan C, Czechtizky W, Patronov A, Bjerrum EJ, Engkvist O. He J, et al. Among authors: czechtizky w. J Cheminform. 2022 Mar 28;14(1):18. doi: 10.1186/s13321-022-00599-3. J Cheminform. 2022. PMID: 35346368 Free PMC article.

3

Machine learning/molecular dynamic protein structure prediction approach to investigate the protein conformational ensemble.

Audagnotto M, Czechtizky W, De Maria L, Käck H, Papoian G, Tornberg L, Tyrchan C, Ulander J. Audagnotto M, et al. Among authors: czechtizky w. Sci Rep. 2022 Jun 15;12(1):10018. doi: 10.1038/s41598-022-13714-z. Sci Rep. 2022. PMID: 35705565 Free PMC article.

4

N-Trifluoromethyl Amines and Azoles: An Underexplored Functional Group in the Medicinal Chemist's Toolbox.

Schiesser S, Chepliaka H, Kollback J, Quennesson T, Czechtizky W, Cox RJ. Schiesser S, et al. Among authors: czechtizky w. J Med Chem. 2020 Nov 12;63(21):13076-13089. doi: 10.1021/acs.jmedchem.0c01457. Epub 2020 Oct 28. J Med Chem. 2020. PMID: 33112606

5

Automated high-throughput in vitro assays to identify metabolic hotspots and protease stability of structurally diverse, pharmacologically active peptides for inhalation.

Wesche F, De Maria L, Leek T, Narjes F, Bird J, Su W, Czechtizky W. Wesche F, et al. Among authors: czechtizky w. J Pharm Biomed Anal. 2022 Mar 20;211:114518. doi: 10.1016/j.jpba.2021.114518. Epub 2021 Dec 11. J Pharm Biomed Anal. 2022. PMID: 35124452

6

How well does molecular simulation reproduce environment-specific conformations of the intrinsically disordered peptides PLP, TP2 and ONEG?

Reid LM, Guzzetti I, Svensson T, Carlsson AC, Su W, Leek T, von Sydow L, Czechtizky W, Miljak M, Verma C, De Maria L, Essex JW. Reid LM, et al. Among authors: czechtizky w. Chem Sci. 2022 Jan 20;13(7):1957-1971. doi: 10.1039/d1sc03496k. eCollection 2022 Feb 16. Chem Sci. 2022. PMID: 35308859 Free PMC article.

7

The powerful symbiosis between synthetic and medicinal chemistry.

Schiesser S, Cox RJ, Czechtizky W. Schiesser S, et al. Among authors: czechtizky w. Future Med Chem. 2021 Jun;13(11):941-944. doi: 10.4155/fmc-2021-0062. Epub 2021 Apr 21. Future Med Chem. 2021. PMID: 33878945 Free article. No abstract available.

8

Advances in the design of new types of inhaled medicines.

Czechtizky W, Su W, Ripa L, Schiesser S, Höijer A, Cox RJ. Czechtizky W, et al. Prog Med Chem. 2022;61:93-162. doi: 10.1016/bs.pmch.2022.04.001. Epub 2022 Jun 2. Prog Med Chem. 2022. PMID: 35753716 Review.

9

Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis.

Cousins DL, Fricero P, Kopf KPM, McColl EJ, Czechtizky W, Lim YH, Harrity JPA. Cousins DL, et al. Among authors: czechtizky w. Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9412-9415. doi: 10.1002/anie.202101297. Epub 2021 Mar 17. Angew Chem Int Ed Engl. 2021. PMID: 33570831 Free PMC article.

10

Design and Synthesis of New Pyrazole-Based Heterotricycles and their Derivatization by Automated Library Synthesis.

Fricero P, Bialy L, Czechtizky W, Méndez M, Harrity JPA. Fricero P, et al. Among authors: czechtizky w. ChemMedChem. 2020 Sep 3;15(17):1634-1638. doi: 10.1002/cmdc.202000187. Epub 2020 Jun 8. ChemMedChem. 2020. PMID: 32427423 Free article.

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