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Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Eur J Med Chem. 2023 Nov 5;259:115695. doi: 10.1016/j.ejmech.2023.115695. Epub 2023 Jul 30.
Eur J Med Chem. 2023.
PMID: 37567058
Free article.
Multitargeting the Action of 5-HT6 Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer's Disease: Can It Work from a Molecular Point of View?
Czarnota-Łydka K, Kucwaj-Brysz K, Pyka P, Haberek W, Podlewska S, Handzlik J.
Czarnota-Łydka K, et al.
Int J Mol Sci. 2022 Aug 7;23(15):8768. doi: 10.3390/ijms23158768.
Int J Mol Sci. 2022.
PMID: 35955902
Free PMC article.
Review.
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First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Pyka P, Haberek W, Więcek M, Szymanska E, Ali W, Cios A, Jastrzębska-Więsek M, Satała G, Podlewska S, Di Giacomo S, Di Sotto A, Garbo S, Karcz T, Lambona C, Marocco F, Latacz G, Sudoł-Tałaj S, Mordyl B, Głuch-Lutwin M, Siwek A, Czarnota-Łydka K, Gogola D, Olejarz-Maciej A, Wilczyńska-Zawal N, Honkisz-Orzechowska E, Starek M, Dąbrowska M, Kucwaj-Brysz K, Fioravanti R, Nasim MJ, Hittinger M, Partyka A, Wesołowska A, Battistelli C, Zwergel C, Handzlik J.
Pyka P, et al. Among authors: czarnota lydka k.
J Med Chem. 2024 Jan 25;67(2):1580-1610. doi: 10.1021/acs.jmedchem.3c02148. Epub 2024 Jan 8.
J Med Chem. 2024.
PMID: 38190615
Free PMC article.
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Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains.
Witek K, Kaczor A, Żesławska E, Podlewska S, Marć MA, Czarnota-Łydka K, Nitek W, Latacz G, Tejchman W, Bischoff M, Jacob C, Handzlik J.
Witek K, et al. Among authors: czarnota lydka k.
Antibiotics (Basel). 2023 Nov 11;12(11):1618. doi: 10.3390/antibiotics12111618.
Antibiotics (Basel). 2023.
PMID: 37998820
Free PMC article.
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Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents.
Sudoł-Tałaj S, Kucwaj-Brysz K, Podlewska S, Kurczab R, Satała G, Mordyl B, Głuch-Lutwin M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Czarnota-Łydka K, Kurowska K, Kubacka M, Żesławska E, Nitek W, Olejarz-Maciej A, Doroz-Płonka A, Partyka A, Latacz G, Wesołowska A, Handzlik J.
Sudoł-Tałaj S, et al. Among authors: czarnota lydka k.
Eur J Med Chem. 2023 Nov 15;260:115756. doi: 10.1016/j.ejmech.2023.115756. Epub 2023 Aug 24.
Eur J Med Chem. 2023.
PMID: 37657272
Free article.
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