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Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver.
Buniatian GH, Weiskirchen R, Weiss TS, Schwinghammer U, Fritz M, Seferyan T, Proksch B, Glaser M, Lourhmati A, Buadze M, Borkham-Kamphorst E, Gaunitz F, Gleiter CH, Lang T, Schaeffeler E, Tremmel R, Cynis H, Frey WH 2nd, Gebhardt R, Friedman SL, Mikulits W, Schwab M, Danielyan L. Buniatian GH, et al. Among authors: cynis h. Cells. 2020 Feb 17;9(2):452. doi: 10.3390/cells9020452. Cells. 2020. PMID: 32089540 Free PMC article.
Consequences of Amyloid-β Deficiency for the Liver.
Buniatian GH, Schwinghammer U, Tremmel R, Cynis H, Weiss TS, Weiskirchen R, Lauschke VM, Youhanna S, Ramos I, Valcarcel M, Seferyan T, Rahfeld JU, Rieckmann V, Klein K, Buadze M, Weber V, Kolak V, Gebhardt R, Friedman SL, Müller UC, Schwab M, Danielyan L. Buniatian GH, et al. Among authors: cynis h. Adv Sci (Weinh). 2024 Mar 2:e2307734. doi: 10.1002/advs.202307734. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 38430535
Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.
Hartlage-Rübsamen M, Waniek A, Meissner J, Morawski M, Schilling S, Jäger C, Kleinschmidt M, Cynis H, Kehlen A, Arendt T, Demuth HU, Rossner S. Hartlage-Rübsamen M, et al. Among authors: cynis h. Acta Neuropathol. 2015 Apr;129(4):565-83. doi: 10.1007/s00401-015-1395-2. Epub 2015 Feb 11. Acta Neuropathol. 2015. PMID: 25666182 Free PMC article.
Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology.
Gnoth K, Piechotta A, Kleinschmidt M, Konrath S, Schenk M, Taudte N, Ramsbeck D, Rieckmann V, Geissler S, Eichentopf R, Barendrecht S, Hartlage-Rübsamen M, Demuth HU, Roßner S, Cynis H, Rahfeld JU, Schilling S. Gnoth K, et al. Among authors: cynis h. Alzheimers Res Ther. 2020 Nov 14;12(1):149. doi: 10.1186/s13195-020-00719-x. Alzheimers Res Ther. 2020. PMID: 33189132 Free PMC article.
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life.
Uhlmann RE, Rother C, Rasmussen J, Schelle J, Bergmann C, Ullrich Gavilanes EM, Fritschi SK, Buehler A, Baumann F, Skodras A, Al-Shaana R, Beschorner N, Ye L, Kaeser SA, Obermüller U, Christensen S, Kartberg F, Stavenhagen JB, Rahfeld JU, Cynis H, Qian F, Weinreb PH, Bussiere T, Walker LC, Staufenbiel M, Jucker M. Uhlmann RE, et al. Among authors: cynis h. Nat Neurosci. 2020 Dec;23(12):1580-1588. doi: 10.1038/s41593-020-00737-w. Epub 2020 Nov 16. Nat Neurosci. 2020. PMID: 33199898 Free PMC article.
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice.
Barendrecht S, Schreurs A, Geissler S, Sabanov V, Ilse V, Rieckmann V, Eichentopf R, Künemund A, Hietel B, Wussow S, Hoffmann K, Körber-Ferl K, Pandey R, Carter GW, Demuth HU, Holzer M, Roßner S, Schilling S, Preuss C, Balschun D, Cynis H. Barendrecht S, et al. Among authors: cynis h. Alzheimers Res Ther. 2023 Jan 14;15(1):16. doi: 10.1186/s13195-022-01144-y. Alzheimers Res Ther. 2023. PMID: 36641439 Free PMC article.
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.
Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Rossner S. Hartlage-Rübsamen M, et al. Among authors: cynis h. Acta Neuropathol. 2011 Jun;121(6):705-19. doi: 10.1007/s00401-011-0806-2. Epub 2011 Feb 8. Acta Neuropathol. 2011. PMID: 21301857 Free PMC article.
45 results