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Modulation of autophagy: a Phase II study of vorinostat plus hydroxychloroquine versus regorafenib in chemotherapy-refractory metastatic colorectal cancer (mCRC).
Arora SP, Tenner L, Sarantopoulos J, Morris J, Liu Q, Mendez JA, Curiel T, Michalek J, Mahalingam D. Arora SP, et al. Among authors: curiel t. Br J Cancer. 2022 Oct;127(6):1153-1161. doi: 10.1038/s41416-022-01892-6. Epub 2022 Jun 23. Br J Cancer. 2022. PMID: 35739299 Free PMC article. Clinical Trial.
Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.
Mahalingam D, Mita M, Sarantopoulos J, Wood L, Amaravadi RK, Davis LE, Mita AC, Curiel TJ, Espitia CM, Nawrocki ST, Giles FJ, Carew JS. Mahalingam D, et al. Among authors: curiel tj. Autophagy. 2014 Aug;10(8):1403-14. doi: 10.4161/auto.29231. Epub 2014 May 20. Autophagy. 2014. PMID: 24991835 Free PMC article. Clinical Trial.
Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment.
Liu Y, Pandeswara S, Dao V, Padrón Á, Drerup JM, Lao S, Liu A, Hurez V, Curiel TJ. Liu Y, et al. Cancer Res. 2017 Jan 15;77(2):520-531. doi: 10.1158/0008-5472.CAN-16-1140. Epub 2016 Oct 13. Cancer Res. 2017. PMID: 27737881 Free PMC article.
A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.
Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JAL, Kellogg DL Jr. Kraig E, et al. Exp Gerontol. 2018 May;105:53-69. doi: 10.1016/j.exger.2017.12.026. Epub 2018 Feb 3. Exp Gerontol. 2018. PMID: 29408453 Free PMC article. Clinical Trial.
Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer.
Svatek RS, Ji N, de Leon E, Mukherjee NZ, Kabra A, Hurez V, Nicolas M, Michalek JE, Javors M, Wheeler K, Sharp ZD, Livi CB, Shu ZJ, Henkes D, Curiel TJ. Svatek RS, et al. Cancer Immunol Res. 2019 Mar;7(3):466-475. doi: 10.1158/2326-6066.CIR-18-0336. Epub 2018 Dec 18. Cancer Immunol Res. 2019. PMID: 30563829 Free PMC article. Clinical Trial.
CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation.
Reyes RM, Deng Y, Zhang D, Ji N, Mukherjee N, Wheeler K, Gupta HB, Padron AS, Kancharla A, Zhang C, Garcia M, Kornepati AVR, Boyman O, Conejo-Garcia JR, Svatek RS, Curiel TJ. Reyes RM, et al. J Immunother Cancer. 2021 Apr;9(4):e002051. doi: 10.1136/jitc-2020-002051. J Immunother Cancer. 2021. PMID: 33849925 Free PMC article.
179 results