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Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB. Halby L, et al. Among authors: cura v. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170072. doi: 10.1098/rstb.2017.0072. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29685976 Free PMC article.
Expression, purification, crystallization and preliminary crystallographic study of isolated modules of the mouse coactivator-associated arginine methyltransferase 1.
Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J. Troffer-Charlier N, et al. Among authors: cura v. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):330-3. doi: 10.1107/S1744309107011785. Epub 2007 Mar 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17401209 Free PMC article.
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Iannelli G, Milite C, Marechal N, Cura V, Bonnefond L, Troffer-Charlier N, Feoli A, Rescigno D, Wang Y, Cipriano A, Viviano M, Bedford MT, Cavarelli J, Castellano S, Sbardella G. Iannelli G, et al. Among authors: cura v. J Med Chem. 2022 Sep 8;65(17):11574-11606. doi: 10.1021/acs.jmedchem.2c00252. Epub 2022 Apr 28. J Med Chem. 2022. PMID: 35482954 Free PMC article.
28 results