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An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma.
de Jong MME, Fokkema C, Papazian N, Czeti Á, Appelman MK, Vermeulen M, van Heusden T, Hoogenboezem RM, van Beek G, Tahri S, Sanders MA, van de Woestijne PC, Gay F, Moreau P, Büttner-Herold M, Bruns H, van Duin M, Broijl A, Sonneveld P, Cupedo T. de Jong MME, et al. Among authors: cupedo t. Nat Immunol. 2024 May;25(5):820-833. doi: 10.1038/s41590-024-01808-x. Epub 2024 Apr 10. Nat Immunol. 2024. PMID: 38600356
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape.
de Jong MME, Kellermayer Z, Papazian N, Tahri S, Hofste Op Bruinink D, Hoogenboezem R, Sanders MA, van de Woestijne PC, Bos PK, Khandanpour C, Vermeulen J, Moreau P, van Duin M, Broijl A, Sonneveld P, Cupedo T. de Jong MME, et al. Among authors: cupedo t. Nat Immunol. 2021 Jun;22(6):769-780. doi: 10.1038/s41590-021-00931-3. Epub 2021 May 20. Nat Immunol. 2021. PMID: 34017122 Clinical Trial.
Bone marrow inflammation in haematological malignancies.
de Jong MME, Chen L, Raaijmakers MHGP, Cupedo T. de Jong MME, et al. Among authors: cupedo t. Nat Rev Immunol. 2024 Mar 15. doi: 10.1038/s41577-024-01003-x. Online ahead of print. Nat Rev Immunol. 2024. PMID: 38491073 Review.
Identification of High-Risk Multiple Myeloma With a Plasma Cell Leukemia-Like Transcriptomic Profile.
Hofste Op Bruinink D, Kuiper R, van Duin M, Cupedo T, van der Velden VHJ, Hoogenboezem R, van der Holt B, Beverloo HB, Valent ET, Vermeulen M, Gay F, Broijl A, Avet-Loiseau H, Munshi NC, Musto P, Moreau P, Zweegman S, van de Donk NWCJ, Sonneveld P. Hofste Op Bruinink D, et al. Among authors: cupedo t. J Clin Oncol. 2022 Sep 20;40(27):3132-3150. doi: 10.1200/JCO.21.01217. Epub 2022 Mar 31. J Clin Oncol. 2022. PMID: 35357885 Free PMC article.
A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML.
Chen L, Pronk E, van Dijk C, Bian Y, Feyen J, van Tienhoven T, Yildirim M, Pisterzi P, de Jong MME, Bastidas A, Hoogenboezem RM, Wevers C, Bindels EM, Löwenberg B, Cupedo T, Sanders MA, Raaijmakers MHGP. Chen L, et al. Among authors: cupedo t. Blood Cancer Discov. 2023 Sep 1;4(5):394-417. doi: 10.1158/2643-3230.BCD-23-0043. Blood Cancer Discov. 2023. PMID: 37470778 Free PMC article.
Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation.
Bar-Ephraim YE, Cornelissen F, Papazian N, Konijn T, Hoogenboezem RM, Sanders MA, Westerman BA, Gönültas M, Kwekkeboom J, Den Haan JMM, Reijmers RM, Mebius RE, Cupedo T. Bar-Ephraim YE, et al. Among authors: cupedo t. Cell Rep. 2017 Oct 17;21(3):823-833. doi: 10.1016/j.celrep.2017.09.070. Cell Rep. 2017. PMID: 29045847 Free article.
Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells.
Romera-Hernández M, Aparicio-Domingo P, Papazian N, Karrich JJ, Cornelissen F, Hoogenboezem RM, Samsom JN, Cupedo T. Romera-Hernández M, et al. Among authors: cupedo t. Cell Rep. 2020 Jan 7;30(1):37-45.e3. doi: 10.1016/j.celrep.2019.11.115. Cell Rep. 2020. PMID: 31914395 Free article.
A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.
Hoorweg K, Narang P, Li Z, Thuery A, Papazian N, Withers DR, Coles MC, Cupedo T. Hoorweg K, et al. Among authors: cupedo t. J Immunol. 2015 Nov 1;195(9):4257-4263. doi: 10.4049/jimmunol.1402584. Epub 2015 Sep 16. J Immunol. 2015. PMID: 26378073 Free PMC article.
71 results