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Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions.
Brandolini L, d'Angelo M, Novelli R, Castelli V, Giorgio C, Sirico A, Cocchiaro P, D'Egidio F, Benedetti E, Cristiano C, Bugatti A, Ruocco A, Amendola PG, Talarico C, Manelfi C, Iaconis D, Beccari A, Quadros AU, Cunha TM, Caruso A, Russo R, Cimini A, Aramini A, Allegretti M. Brandolini L, et al. Among authors: cunha tm. Cell Death Dis. 2022 May 25;13(5):500. doi: 10.1038/s41419-022-04964-w. Cell Death Dis. 2022. PMID: 35614037 Free PMC article.
Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice.
Cunha TM, Barsante MM, Guerrero AT, Verri WA Jr, Ferreira SH, Coelho FM, Bertini R, Di Giacinto C, Allegretti M, Cunha FQ, Teixeira MM. Cunha TM, et al. Among authors: cunha fq. Br J Pharmacol. 2008 May;154(2):460-70. doi: 10.1038/bjp.2008.94. Epub 2008 Mar 24. Br J Pharmacol. 2008. PMID: 18362895 Free PMC article.
Neutrophils recruited by CXCR1/2 signalling mediate post-incisional pain.
Carreira EU, Carregaro V, Teixeira MM, Moriconi A, Aramini A, Verri WA Jr, Ferreira SH, Cunha FQ, Cunha TM. Carreira EU, et al. Among authors: cunha tm, cunha fq. Eur J Pain. 2013 May;17(5):654-63. doi: 10.1002/j.1532-2149.2012.00240.x. Epub 2012 Nov 7. Eur J Pain. 2013. PMID: 23132735
Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief.
Moriconi A, Cunha TM, Souza GR, Lopes AH, Cunha FQ, Carneiro VL, Pinto LG, Brandolini L, Aramini A, Bizzarri C, Bianchini G, Beccari AR, Fanton M, Bruno A, Costantino G, Bertini R, Galliera E, Locati M, Ferreira SH, Teixeira MM, Allegretti M. Moriconi A, et al. Among authors: cunha tm, cunha fq. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16937-42. doi: 10.1073/pnas.1417365111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385614 Free PMC article.
C5a and pain development: An old molecule, a new target.
Quadros AU, Cunha TM. Quadros AU, et al. Among authors: cunha tm. Pharmacol Res. 2016 Oct;112:58-67. doi: 10.1016/j.phrs.2016.02.004. Epub 2016 Feb 11. Pharmacol Res. 2016. PMID: 26855316 Review.
414 results