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Page 1
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.
Qiu X, Mistry A, Ammirati MJ, Chrunyk BA, Clark RW, Cong Y, Culp JS, Danley DE, Freeman TB, Geoghegan KF, Griffor MC, Hawrylik SJ, Hayward CM, Hensley P, Hoth LR, Karam GA, Lira ME, Lloyd DB, McGrath KM, Stutzman-Engwall KJ, Subashi AK, Subashi TA, Thompson JF, Wang IK, Zhao H, Seddon AP. Qiu X, et al. Among authors: culp js. Nat Struct Mol Biol. 2007 Feb;14(2):106-13. doi: 10.1038/nsmb1197. Epub 2007 Jan 21. Nat Struct Mol Biol. 2007. PMID: 17237796
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
Cunningham D, Danley DE, Geoghegan KF, Griffor MC, Hawkins JL, Subashi TA, Varghese AH, Ammirati MJ, Culp JS, Hoth LR, Mansour MN, McGrath KM, Seddon AP, Shenolikar S, Stutzman-Engwall KJ, Warren LC, Xia D, Qiu X. Cunningham D, et al. Among authors: culp js. Nat Struct Mol Biol. 2007 May;14(5):413-9. doi: 10.1038/nsmb1235. Epub 2007 Apr 15. Nat Struct Mol Biol. 2007. PMID: 17435765
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Huard K, Ahn K, Amor P, Beebe DA, Borzilleri KA, Chrunyk BA, Coffey SB, Cong Y, Conn EL, Culp JS, Dowling MS, Gorgoglione MF, Gutierrez JA, Knafels JD, Lachapelle EA, Pandit J, Parris KD, Perez S, Pfefferkorn JA, Price DA, Raymer B, Ross TT, Shavnya A, Smith AC, Subashi TA, Tesz GJ, Thuma BA, Tu M, Weaver JD, Weng Y, Withka JM, Xing G, Magee TV. Huard K, et al. Among authors: culp js. J Med Chem. 2017 Sep 28;60(18):7835-7849. doi: 10.1021/acs.jmedchem.7b00947. Epub 2017 Sep 11. J Med Chem. 2017. PMID: 28853885
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Hall J, et al. PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017. PLoS One. 2017. PMID: 28934246 Free PMC article.
Immunohistochemical localization of PDE10A in the rat brain.
Seeger TF, Bartlett B, Coskran TM, Culp JS, James LC, Krull DL, Lanfear J, Ryan AM, Schmidt CJ, Strick CA, Varghese AH, Williams RD, Wylie PG, Menniti FS. Seeger TF, et al. Among authors: culp js. Brain Res. 2003 Sep 26;985(2):113-26. doi: 10.1016/s0006-8993(03)02754-9. Brain Res. 2003. PMID: 12967715
Crystal structure of varicella-zoster virus protease.
Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS. Qiu X, et al. Among authors: culp js. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. doi: 10.1073/pnas.94.7.2874. Proc Natl Acad Sci U S A. 1997. PMID: 9096314 Free PMC article.
Unique fold and active site in cytomegalovirus protease.
Qiu X, Culp JS, DiLella AG, Hellmig B, Hoog SS, Janson CA, Smith WW, Abdel-Meguid SS. Qiu X, et al. Among authors: culp js. Nature. 1996 Sep 19;383(6597):275-9. doi: 10.1038/383275a0. Nature. 1996. PMID: 8805707
29 results