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Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore.
Lim YC, Ensbey KS, Offenhäuser C, D'souza RCJ, Cullen JK, Stringer BW, Quek H, Bruce ZC, Kijas A, Cianfanelli V, Mahboubi B, Smith F, Jeffree RL, Wiesmüeller L, Wiegmans AP, Bain A, Lombard FJ, Roberts TL, Khanna KK, Lavin MF, Kim B, Hamerlik P, Johns TG, Coster MJ, Boyd AW, Day BW. Lim YC, et al. Among authors: cullen jk. Neuro Oncol. 2020 Feb 20;22(2):216-228. doi: 10.1093/neuonc/noz159. Neuro Oncol. 2020. PMID: 31504812 Free PMC article.
Cryptic Epoxytiglianes from the Kernels of the Blushwood Tree (Fontainea picrosperma).
Chianese G, Amin HIM, Maioli C, Reddell P, Parsons P, Cullen J, Johns J, Handoko H, Boyle G, Appendino G, Taglialatela-Scafati O, Gaeta S. Chianese G, et al. J Nat Prod. 2022 Aug 26;85(8):1959-1966. doi: 10.1021/acs.jnatprod.2c00226. Epub 2022 Aug 16. J Nat Prod. 2022. PMID: 35973043 Free PMC article. Review.
Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds.
Powell LC, Cullen JK, Boyle GM, De Ridder T, Yap PY, Xue W, Pierce CJ, Pritchard MF, Menzies GE, Abdulkarim M, Adams JYM, Stokniene J, Francis LW, Gumbleton M, Johns J, Hill KE, Jones AV, Parsons PG, Reddell P, Thomas DW. Powell LC, et al. Among authors: cullen jk. Sci Transl Med. 2022 Sep 14;14(662):eabn3758. doi: 10.1126/scitranslmed.abn3758. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103515
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade.
Cullen JK, Yap PY, Ferguson B, Bruce ZC, Koyama M, Handoko H, Hendrawan K, Simmons JL, Brooks KM, Johns J, Wilson ES, de Souza MMA, Broit N, Stewart P, Shelley D, McMahon T, Ogbourne SM, Nguyen TH, Lim YC, Pagani A, Appendino G, Gordon VA, Reddell PW, Boyle GM, Parsons PG. Cullen JK, et al. J Immunother Cancer. 2024 Apr 24;12(4):e006602. doi: 10.1136/jitc-2022-006602. J Immunother Cancer. 2024. PMID: 38658031 Free PMC article.
58 results