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mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures.
J Neurosci. 2023 Feb 1;43(5):827-845. doi: 10.1523/JNEUROSCI.1354-22.2022. Epub 2022 Dec 16.
J Neurosci. 2023.
PMID: 36526374
Free PMC article.
Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission.
McCabe MP, Cullen ER, Barrows CM, Shore AN, Tooke KI, Laprade KA, Stafford JM, Weston MC.
McCabe MP, et al. Among authors: cullen er.
Elife. 2020 Mar 3;9:e51440. doi: 10.7554/eLife.51440.
Elife. 2020.
PMID: 32125271
Free PMC article.
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Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy.
Shore AN, Colombo S, Tobin WF, Petri S, Cullen ER, Dominguez S, Bostick CD, Beaumont MA, Williams D, Khodagholy D, Yang M, Lutz CM, Peng Y, Gelinas JN, Goldstein DB, Boland MJ, Frankel WN, Weston MC.
Shore AN, et al. Among authors: cullen er.
Cell Rep. 2020 Oct 27;33(4):108303. doi: 10.1016/j.celrep.2020.108303.
Cell Rep. 2020.
PMID: 33113364
Free PMC article.
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Glutamate's Secret Interictal Life.
Cullen ER, Weston MC.
Cullen ER, et al.
Epilepsy Curr. 2021 Sep 17;21(6):460-462. doi: 10.1177/15357597211043728. eCollection 2021 Nov-Dec.
Epilepsy Curr. 2021.
PMID: 34924859
Free PMC article.
No abstract available.
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Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss.
Tariq K, Cullen E, Getz SA, Conching AKS, Goyette AR, Prina ML, Wang W, Li M, Weston MC, Luikart BW.
Tariq K, et al.
Cell Rep. 2022 Nov 1;41(5):111574. doi: 10.1016/j.celrep.2022.111574.
Cell Rep. 2022.
PMID: 36323257
Free PMC article.
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Hyperactivity of mTORC1 and mTORC2-dependent signaling mediate epilepsy downstream of somatic PTEN loss.
Cullen ER, Safari M, Mittelstadt I, Weston MC.
Cullen ER, et al.
bioRxiv [Preprint]. 2024 Jan 11:2023.08.18.553856. doi: 10.1101/2023.08.18.553856.
bioRxiv. 2024.
PMID: 37645923
Free PMC article.
Updated.
Preprint.
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Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss.
Cullen ER, Safari M, Mittelstadt I, Weston MC.
Cullen ER, et al.
Elife. 2024 Mar 6;12:RP91323. doi: 10.7554/eLife.91323.
Elife. 2024.
PMID: 38446016
Free PMC article.
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Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks.
Chouhan D, Gordián Vélez WJ, Struzyna LA, Adewole DO, Cullen ER, Burrell JC, O'Donnell JC, Cullen DK.
Chouhan D, et al. Among authors: cullen er.
Front Mol Neurosci. 2024 Mar 25;17:1346696. doi: 10.3389/fnmol.2024.1346696. eCollection 2024.
Front Mol Neurosci. 2024.
PMID: 38590432
Free PMC article.
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