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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: cui h. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
Corrigendum to "Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells" [Biomed. Pharmacother. 131 (2020) 110788].
Rostami J, Jäntti M, Cui H, Rinne MK, Kukkonen JP, Falk A, Erlandsson A, Myöhänen T. Rostami J, et al. Among authors: cui h. Biomed Pharmacother. 2021 Jan;133:111019. doi: 10.1016/j.biopha.2020.111019. Epub 2020 Nov 24. Biomed Pharmacother. 2021. PMID: 33246737 Free article. No abstract available.
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.
Kilpeläinen TP, Pätsi HT, Svarcbahs R, Julku UH, Eteläinen TS, Cui H, Auno S, Sipari N, Norrbacka S, Leino TO, Jäntti M, Myöhänen TT, Wallén EAA. Kilpeläinen TP, et al. Among authors: cui h. J Med Chem. 2023 Jun 8;66(11):7475-7496. doi: 10.1021/acs.jmedchem.3c00235. Epub 2023 May 29. J Med Chem. 2023. PMID: 37248563 Free PMC article.
5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.
Pätsi HT, Kilpeläinen TP, Jumppanen M, Uhari-Väänänen J, Wielendaele PV, De Lorenzo F, Cui H, Auno S, Saharinen J, Seppälä E, Sipari N, Savinainen J, De Meester I, Lambeir AM, Lahtela-Kakkonen M, Myöhänen TT, Wallén EAA. Pätsi HT, et al. Among authors: cui h. J Med Chem. 2024 Apr 11;67(7):5421-5436. doi: 10.1021/acs.jmedchem.3c01993. Epub 2024 Mar 28. J Med Chem. 2024. PMID: 38546708
7,742 results