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Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.
Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Sanchez M, et al. Among authors: cuddy m. Oncotarget. 2018 May 18;9(38):25057-25074. doi: 10.18632/oncotarget.25285. eCollection 2018 May 18. Oncotarget. 2018. PMID: 29861853 Free PMC article.
Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines.
Ravanan P, Sano R, Talwar P, Ogasawara S, Matsuzawa S, Cuddy M, Singh SK, Rao GS, Kondaiah P, Reed JC. Ravanan P, et al. Among authors: cuddy m. Mol Cancer Ther. 2011 Sep;10(9):1635-43. doi: 10.1158/1535-7163.MCT-10-0887. Epub 2011 Jul 11. Mol Cancer Ther. 2011. PMID: 21746806 Free PMC article.
114 results