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Ethanolic extract of Casearia sylvestris and its clerodane diterpen (caseargrewiin F) protect against DNA damage at low concentrations and cause DNA damage at high concentrations in mice's blood cells.
de Oliveira AM, dos Santos AG, Dos Santos RA, Csipak AR, Olivato C, da Silva IC, de Freitas MB, Bassi CL, Cavalheiro AJ, Bolzani VS, Silva DH, Sakamoto-Hojo ET, Takahashi CS, Soares CP. de Oliveira AM, et al. Among authors: csipak ar. Mutagenesis. 2009 Nov;24(6):501-6. doi: 10.1093/mutage/gep034. Epub 2009 Sep 7. Mutagenesis. 2009. PMID: 19736218
Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil.
Prieto AM, Santos AG, Csipak AR, Caliri CM, Silva IC, Arbex MA, Silva FS, Marchi MR, Cavalheiro AJ, Silva DH, Bolzani VS, Soares CP. Prieto AM, et al. Among authors: csipak ar. Toxicol Appl Pharmacol. 2012 Dec 15;265(3):368-72. doi: 10.1016/j.taap.2012.09.005. Epub 2012 Sep 13. Toxicol Appl Pharmacol. 2012. PMID: 22982620 Free article.