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The Penicillium chrysogenum-derived antifungal peptide shows no toxic effects on mammalian cells in the intended therapeutic concentration.
Szappanos H, Szigeti GP, Pál B, Rusznák Z, Szucs G, Rajnavölgyi E, Balla J, Balla G, Nagy E, Leiter E, Pócsi I, Marx F, Csernoch L. Szappanos H, et al. Among authors: csernoch l. Naunyn Schmiedebergs Arch Pharmacol. 2005 Feb;371(2):122-32. doi: 10.1007/s00210-004-1013-7. Epub 2005 Feb 9. Naunyn Schmiedebergs Arch Pharmacol. 2005. PMID: 15702351
Antifungal protein PAF severely affects the integrity of the plasma membrane of Aspergillus nidulans and induces an apoptosis-like phenotype.
Leiter E, Szappanos H, Oberparleiter C, Kaiserer L, Csernoch L, Pusztahelyi T, Emri T, Pócsi I, Salvenmoser W, Marx F. Leiter E, et al. Among authors: csernoch l. Antimicrob Agents Chemother. 2005 Jun;49(6):2445-53. doi: 10.1128/AAC.49.6.2445-2453.2005. Antimicrob Agents Chemother. 2005. PMID: 15917545 Free PMC article.
In vivo application of a small molecular weight antifungal protein of Penicillium chrysogenum (PAF).
Palicz Z, Jenes A, Gáll T, Miszti-Blasius K, Kollár S, Kovács I, Emri M, Márián T, Leiter E, Pócsi I, Csősz E, Kalló G, Hegedűs C, Virág L, Csernoch L, Szentesi P. Palicz Z, et al. Among authors: csernoch l. Toxicol Appl Pharmacol. 2013 May 15;269(1):8-16. doi: 10.1016/j.taap.2013.02.014. Epub 2013 Mar 4. Toxicol Appl Pharmacol. 2013. PMID: 23466426
183 results