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Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Merfeld T, Peng S, Keegan BM, Crowley VM, Brackett CM, Gutierrez A, McCann NR, Reynolds TS, Rhodes MC, Byrd KM, Deng J, Matts RL, Blagg BSJ. Merfeld T, et al. Among authors: crowley vm. Eur J Med Chem. 2023 Oct 5;258:115531. doi: 10.1016/j.ejmech.2023.115531. Epub 2023 Jun 5. Eur J Med Chem. 2023. PMID: 37307624
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, Kinsella TM, Simon GM, Baltgalvis KA, Cravatt BF. Zhang X, et al. Among authors: crowley vm. J Am Chem Soc. 2021 Apr 7;143(13):5141-5149. doi: 10.1021/jacs.1c00990. Epub 2021 Mar 30. J Am Chem Soc. 2021. PMID: 33783207 Free PMC article.
The Proteome-Wide Potential for Reversible Covalency at Cysteine.
Senkane K, Vinogradova EV, Suciu RM, Crowley VM, Zaro BW, Bradshaw JM, Brameld KA, Cravatt BF. Senkane K, et al. Among authors: crowley vm. Angew Chem Int Ed Engl. 2019 Aug 12;58(33):11385-11389. doi: 10.1002/anie.201905829. Epub 2019 Jul 5. Angew Chem Int Ed Engl. 2019. PMID: 31222866 Free PMC article.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF. Vinogradova EV, et al. Among authors: crowley vm. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29. Cell. 2020. PMID: 32730809 Free PMC article.
Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.
Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA. Stothert AR, et al. Among authors: crowley vm. Hum Mol Genet. 2014 Dec 15;23(24):6470-80. doi: 10.1093/hmg/ddu367. Epub 2014 Jul 15. Hum Mol Genet. 2014. PMID: 25027323 Free PMC article.
Development of radamide analogs as Grp94 inhibitors.
Muth A, Crowley V, Khandelwal A, Mishra S, Zhao J, Hall J, Blagg BS. Muth A, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4083-98. doi: 10.1016/j.bmc.2014.05.075. Epub 2014 Jun 12. Bioorg Med Chem. 2014. PMID: 25027801 Free PMC article.
41 results