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Computationally restoring the potency of a clinical antibody against Omicron.
Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW; Tri-lab COVID-19 Consortium; Lillo AM, Sundaram S, Bloom JD, Diamond MS, Crowe JE Jr, Carnahan RH, Faissol DM. Desautels TA, et al. Among authors: crowe je jr. Nature. 2024 May 8. doi: 10.1038/s41586-024-07385-1. Online ahead of print. Nature. 2024. PMID: 38720086
Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates.
Zeitlin L, Cross RW, Woolsey C, West BR, Borisevich V, Agans KN, Prasad AN, Deer DJ, Stuart L, McCavitt-Malvido M, Kim DH, Pettitt J, Crowe JE Jr, Whaley KJ, Veesler D, Dimitrov A, Abelson DM, Geisbert TW, Broder CC. Zeitlin L, et al. Among authors: crowe je jr. Sci Transl Med. 2024 Apr 3;16(741):eadl2055. doi: 10.1126/scitranslmed.adl2055. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569014
Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody.
Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson S, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe JE Jr, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS. Johnson NV, et al. Among authors: crowe je jr. bioRxiv [Preprint]. 2024 Jan 16:2024.01.15.575741. doi: 10.1101/2024.01.15.575741. bioRxiv. 2024. PMID: 38293237 Free PMC article. Preprint.
A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection.
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Chong Z, Whitener BM, Shrihari S, Jethva PN, Gross ML, Crowe JE Jr, Whelan SPJ, Diamond MS, Fremont DH. Adams LJ, et al. Among authors: crowe je jr. Cell Rep Med. 2023 Dec 19;4(12):101305. doi: 10.1016/j.xcrm.2023.101305. Epub 2023 Nov 30. Cell Rep Med. 2023. PMID: 38039973 Free PMC article.
SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes.
Wall SC, Suryadevara N, Kim C, Shiakolas AR, Holt CM, Irbe EB, Wasdin PT, Suresh YP, Binshtein E, Chen EC, Zost SJ, Canfield E, Crowe JE Jr, Thompson-Arildsen MA, Sheward DJ, Carnahan RH, Georgiev IS. Wall SC, et al. Among authors: crowe je jr. Cell Rep Med. 2023 Nov 21;4(11):101267. doi: 10.1016/j.xcrm.2023.101267. Epub 2023 Nov 6. Cell Rep Med. 2023. PMID: 37935199 Free PMC article.
Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology.
Streblow DN, Hirsch AJ, Stanton JJ, Lewis AD, Colgin L, Hessell AJ, Kreklywich CN, Smith JL, Sutton WF, Chauvin D, Woo J, Bimber BN, LeBlanc CN, Acharya SN, O'Roak BJ, Sardar H, Sajadi MM, Tehrani ZR, Walter MR, Martinez-Sobrido L, Kobie JJ, Reader RJ, Olstad KJ, Hobbs TR, Saphire EO, Schendel SL, Carnahan RH, Knoch J, Branco LM, Crowe JE Jr, Van Rompay KKA, Lovalenti P, Vu Truong, Forthal DN, Haigwood NL. Streblow DN, et al. Among authors: crowe je jr. Nat Commun. 2023 Nov 3;14(1):7062. doi: 10.1038/s41467-023-42440-x. Nat Commun. 2023. PMID: 37923717 Free PMC article.
Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination.
Munt JE, Henein S, Adams C, Young E, Hou YJ, Conrad H, Zhu D, Dong S, Kose N, Yount B, Meganck RM, Tse LPV, Kuan G, Balmaseda A, Ricciardi MJ, Watkins DI, Crowe JE Jr, Harris E, DeSilva AM, Baric RS. Munt JE, et al. Among authors: crowe je jr. Cell Host Microbe. 2023 Nov 8;31(11):1850-1865.e5. doi: 10.1016/j.chom.2023.10.004. Epub 2023 Oct 30. Cell Host Microbe. 2023. PMID: 37909048
393 results