Crossan GP - Search Results

1

Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.

Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB. Umansky C, et al. Among authors: crossan gp. Nat Commun. 2022 Feb 8;13(1):745. doi: 10.1038/s41467-022-28242-7. Nat Commun. 2022. PMID: 35136057 Free PMC article.

2

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PHL, McIntyre RE; Sanger Mouse Genetics Project; Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ. Crossan GP, et al. Nat Genet. 2011 Feb;43(2):147-52. doi: 10.1038/ng.752. Epub 2011 Jan 16. Nat Genet. 2011. PMID: 21240276 Free PMC article.

3

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.

Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ. Langevin F, et al. Among authors: crossan gp. Nature. 2011 Jul 6;475(7354):53-8. doi: 10.1038/nature10192. Nature. 2011. PMID: 21734703

4

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Rosado IV, Langevin F, Crossan GP, Takata M, Patel KJ. Rosado IV, et al. Among authors: crossan gp. Nat Struct Mol Biol. 2011 Nov 13;18(12):1432-4. doi: 10.1038/nsmb.2173. Nat Struct Mol Biol. 2011. PMID: 22081012

5

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.

Garaycoechea JI, Crossan GP, Langevin F, Daly M, Arends MJ, Patel KJ. Garaycoechea JI, et al. Among authors: crossan gp. Nature. 2012 Sep 27;489(7417):571-5. doi: 10.1038/nature11368. Epub 2012 Aug 26. Nature. 2012. PMID: 22922648

6

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ. Pontel LB, et al. Among authors: crossan gp. Mol Cell. 2015 Oct 1;60(1):177-88. doi: 10.1016/j.molcel.2015.08.020. Epub 2015 Sep 24. Mol Cell. 2015. PMID: 26412304 Free PMC article.

7

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Louzada S, Yang F, Guilbaud G, Park N, Roerink S, Nik-Zainal S, Stratton MR, Patel KJ. Garaycoechea JI, et al. Among authors: crossan gp. Nature. 2018 Jan 11;553(7687):171-177. doi: 10.1038/nature25154. Epub 2018 Jan 3. Nature. 2018. PMID: 29323295 Free PMC article.

8

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.

Mulderrig L, Garaycoechea JI, Tuong ZK, Millington CL, Dingler FA, Ferdinand JR, Gaul L, Tadross JA, Arends MJ, O'Rahilly S, Crossan GP, Clatworthy MR, Patel KJ. Mulderrig L, et al. Among authors: crossan gp. Nature. 2021 Dec;600(7887):158-163. doi: 10.1038/s41586-021-04133-7. Epub 2021 Nov 24. Nature. 2021. PMID: 34819667

9

The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA.

Crossan GP, Patel KJ. Crossan GP, et al. J Pathol. 2012 Jan;226(2):326-37. doi: 10.1002/path.3002. Epub 2011 Oct 25. J Pathol. 2012. PMID: 21956823 Review.

10

[Aldehydes and Fanconi anaemia: the enemy within].

Langevin FP, Garaycoechea JI, Crossan GP, Patel KJ. Langevin FP, et al. Among authors: crossan gp. Med Sci (Paris). 2013 Apr;29(4):361-4. doi: 10.1051/medsci/2013294009. Epub 2013 Apr 26. Med Sci (Paris). 2013. PMID: 23621931 Free article. French. No abstract available.

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