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Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors.
Hajji N, Garcia-Revilla J, Soto MS, Perryman R, Symington J, Quarles CC, Healey DR, Guo Y, Orta-Vázquez ML, Mateos-Cordero S, Shah K, Bomalaski J, Anichini G, Tzakos AG, Crook T, O'Neill K, Scheck AC, Venero JL, Syed N. Hajji N, et al. Among authors: crook t. J Clin Invest. 2022 Mar 15;132(6):e142137. doi: 10.1172/JCI142137. J Clin Invest. 2022. PMID: 35113813 Free PMC article.
A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma.
Hall PE, Lewis R, Syed N, Shaffer R, Evanson J, Ellis S, Williams M, Feng X, Johnston A, Thomson JA, Harris FP, Jena R, Matys T, Jefferies S, Smith K, Wu BW, Bomalaski JS, Crook T, O'Neill K, Paraskevopoulos D, Khadeir RS, Sheaff M, Pacey S, Plowman PN, Szlosarek PW. Hall PE, et al. Among authors: crook t. Clin Cancer Res. 2019 May 1;25(9):2708-2716. doi: 10.1158/1078-0432.CCR-18-3729. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796035 Clinical Trial.
Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM.
Przystal JM, Hajji N, Khozoie C, Renziehausen A, Zeng Q, Abaitua F, Hajitou A, Suwan K, Want E, Bomalaski J, Szlosarek P, O'Neill K, Crook T, Syed N. Przystal JM, et al. Among authors: crook t. Cell Death Dis. 2018 Dec 13;9(12):1192. doi: 10.1038/s41419-018-1195-4. Cell Death Dis. 2018. PMID: 30546006 Free PMC article.
Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid.
Tsiailanis AD, Renziehausen A, Kiriakidi S, Vrettos EI, Markopoulos GS, Sayyad N, Hirmiz B, Aguilar MI, Del Borgo MP, Kolettas E, Widdop RE, Mavromoustakos T, Crook T, Syed N, Tzakos AG. Tsiailanis AD, et al. Among authors: crook t. Free Radic Biol Med. 2020 Nov 20;160:391-402. doi: 10.1016/j.freeradbiomed.2020.08.007. Epub 2020 Aug 18. Free Radic Biol Med. 2020. PMID: 32822744
Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N. Perryman R, et al. Among authors: crook t. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119. doi: 10.1073/pnas.2116289119. Epub 2022 Aug 2. Proc Natl Acad Sci U S A. 2022. PMID: 35917342 Free PMC article.
379 results