Crichton PG - Search Results

1

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis.

Cavalieri R, Hazebroek MK, Cotrim CA, Lee Y, Kunji ERS, Jastroch M, Keipert S, Crichton PG. Cavalieri R, et al. Among authors: crichton pg. Mol Metab. 2022 Aug;62:101526. doi: 10.1016/j.molmet.2022.101526. Epub 2022 Jun 9. Mol Metab. 2022. PMID: 35691529 Free PMC article.

2

Novel uncoupling proteins.

Affourtit C, Crichton PG, Parker N, Brand MD. Affourtit C, et al. Among authors: crichton pg. Novartis Found Symp. 2007;287:70-80; discussion 80-91. Novartis Found Symp. 2007. PMID: 18074632 Review.

3

Not all mitochondrial carrier proteins support permeability transition pore formation: no involvement of uncoupling protein 1.

Crichton PG, Parker N, Vidal-Puig AJ, Brand MD. Crichton PG, et al. Biosci Rep. 2009 Dec 15;30(3):187-92. doi: 10.1042/BSR20090063. Biosci Rep. 2009. PMID: 19622065 Free PMC article.

4

Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria.

Parker N, Crichton PG, Vidal-Puig AJ, Brand MD. Parker N, et al. Among authors: crichton pg. J Bioenerg Biomembr. 2009 Aug;41(4):335-42. doi: 10.1007/s10863-009-9232-8. Epub 2009 Aug 25. J Bioenerg Biomembr. 2009. PMID: 19705265

5

Mitochondrial carriers function as monomers.

Kunji ER, Crichton PG. Kunji ER, et al. Among authors: crichton pg. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):817-31. doi: 10.1016/j.bbabio.2010.03.023. Epub 2010 Mar 31. Biochim Biophys Acta. 2010. PMID: 20362544 Free article. Review.

6

Lipid, detergent, and Coomassie Blue G-250 affect the migration of small membrane proteins in blue native gels: mitochondrial carriers migrate as monomers not dimers.

Crichton PG, Harding M, Ruprecht JJ, Lee Y, Kunji ER. Crichton PG, et al. J Biol Chem. 2013 Jul 26;288(30):22163-73. doi: 10.1074/jbc.M113.484329. Epub 2013 Jun 6. J Biol Chem. 2013. PMID: 23744064 Free PMC article.

7

Brown fat in a protoendothermic mammal fuels eutherian evolution.

Oelkrug R, Goetze N, Exner C, Lee Y, Ganjam GK, Kutschke M, Müller S, Stöhr S, Tschöp MH, Crichton PG, Heldmaier G, Jastroch M, Meyer CW. Oelkrug R, et al. Among authors: crichton pg. Nat Commun. 2013;4:2140. doi: 10.1038/ncomms3140. Nat Commun. 2013. PMID: 23860571 Free PMC article.

8

Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism.

Ruprecht JJ, Hellawell AM, Harding M, Crichton PG, McCoy AJ, Kunji ER. Ruprecht JJ, et al. Among authors: crichton pg. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E426-34. doi: 10.1073/pnas.1320692111. Epub 2014 Jan 13. Proc Natl Acad Sci U S A. 2014. PMID: 24474793 Free PMC article.

9

Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers.

Crichton PG, Lee Y, Ruprecht JJ, Cerson E, Thangaratnarajah C, King MS, Kunji ER. Crichton PG, et al. J Biol Chem. 2015 Mar 27;290(13):8206-17. doi: 10.1074/jbc.M114.616607. Epub 2015 Feb 4. J Biol Chem. 2015. PMID: 25653283 Free PMC article.

10

Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin.

Lee Y, Willers C, Kunji ER, Crichton PG. Lee Y, et al. Among authors: crichton pg. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6973-8. doi: 10.1073/pnas.1503833112. Epub 2015 May 18. Proc Natl Acad Sci U S A. 2015. PMID: 26038550 Free PMC article.

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