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Page 1
Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis.
Kang J, Postigo-Fernandez J, Kim K, Zhu C, Yu J, Meroni M, Mayfield B, Bartolomé A, Dapito DH, Ferrante AW Jr, Dongiovanni P, Valenti L, Creusot RJ, Pajvani UB. Kang J, et al. Among authors: creusot rj. JCI Insight. 2023 Feb 8;8(3):e165369. doi: 10.1172/jci.insight.165369. JCI Insight. 2023. PMID: 36752206 Free PMC article.
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation.
Rogava M, Aprati TJ, Chi WY, Melms JC, Hug C, Davis SH, Earlie EM, Chung C, Deshmukh SK, Wu S, Sledge G, Tang S, Ho P, Amin AD, Caprio L, Gurjao C, Tagore S, Ngo B, Lee MJ, Zanetti G, Wang Y, Chen S, Ge W, Melo LMN, Allies G, Rösler J, Gibney GT, Schmitz OJ, Sykes M, Creusot RJ, Tüting T, Schadendorf D, Röcken M, Eigentler TK, Molotkov A, Mintz A, Bakhoum SF, Beyaz S, Cantley LC, Sorger PK, Meckelmann SW, Tasdogan A, Liu D, Laughney AM, Izar B. Rogava M, et al. Among authors: creusot rj. Nat Cancer. 2024 Mar;5(3):433-447. doi: 10.1038/s43018-023-00704-x. Epub 2024 Jan 29. Nat Cancer. 2024. PMID: 38286827
Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals.
Du W, Wang J, Kuo T, Wang L, McKimpson WM, Son J, Watanabe H, Kitamoto T, Lee Y, Creusot RJ, Ratner LE, McCune K, Chen YW, Grubbs BH, Thornton ME, Fan J, Sultana N, Diaz BS, Balasubramanian I, Gao N, Belvedere S, Accili D. Du W, et al. Among authors: creusot rj. J Clin Invest. 2022 Dec 15;132(24):e162720. doi: 10.1172/JCI162720. J Clin Invest. 2022. PMID: 36282594 Free PMC article.
Epitope-based precision immunotherapy of Type 1 diabetes.
Firdessa Fite R, Bechi Genzano C, Mallone R, Creusot RJ. Firdessa Fite R, et al. Among authors: creusot rj. Hum Vaccin Immunother. 2023 Dec 31;19(1):2154098. doi: 10.1080/21645515.2022.2154098. Epub 2023 Jan 19. Hum Vaccin Immunother. 2023. PMID: 36656048 Free PMC article.
Modeling human T1D-associated autoimmune processes.
Khosravi-Maharlooei M, Madley R, Borsotti C, Ferreira LMR, Sharp RC, Brehm MA, Greiner DL, Parent AV, Anderson MS, Sykes M, Creusot RJ. Khosravi-Maharlooei M, et al. Among authors: creusot rj. Mol Metab. 2022 Feb;56:101417. doi: 10.1016/j.molmet.2021.101417. Epub 2021 Dec 10. Mol Metab. 2022. PMID: 34902607 Free PMC article. Review.
Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.
Khosravi-Maharlooei M, Li H, Hoelzl M, Zhao G, Ruiz A, Misra A, Li Y, Teteloshvili N, Nauman G, Danzl N, Ding X, Pinker EY, Obradovic A, Yang YG, Iuga A, Creusot RJ, Winchester R, Sykes M. Khosravi-Maharlooei M, et al. Among authors: creusot rj. J Autoimmun. 2021 May;119:102612. doi: 10.1016/j.jaut.2021.102612. Epub 2021 Feb 19. J Autoimmun. 2021. PMID: 33611150 Free PMC article.
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