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Elevated asleep blood pressure and non-dipper 24h patterning best predict risk for heart failure that can be averted by bedtime hypertension chronotherapy: A review of the published literature.
Hermida RC, Mojón A, Fernández JR, Hermida-Ayala RG, Crespo JJ, Ríos MT, Domínguez-Sardiña M, Otero A, Smolensky MH. Hermida RC, et al. Among authors: crespo jj. Chronobiol Int. 2023 Jan;40(1):63-82. doi: 10.1080/07420528.2021.1939367. Epub 2021 Jun 30. Chronobiol Int. 2023. PMID: 34190016 Review.
Guidelines for the design and conduct of human clinical trials on ingestion-time differences - chronopharmacology and chronotherapy - of hypertension medications.
Hermida RC, Smolensky MH, Balan H, Castriotta RJ, Crespo JJ, Dagan Y, El-Toukhy S, Fernández JR, FitzGerald GA, Fujimura A, Geng YJ, Hermida-Ayala RG, Machado AP, Menna-Barreto L, Mojón A, Otero A, Rudic RD, Schernhammer E, Skarke C, Steen TY, Young ME, Zhao X. Hermida RC, et al. Among authors: crespo jj. Chronobiol Int. 2021 Jan;38(1):1-26. doi: 10.1080/07420528.2020.1850468. Epub 2020 Dec 20. Chronobiol Int. 2021. PMID: 33342316 Free PMC article. Clinical Trial.
Cardiovascular disease risk stratification by the Framigham score is markedly improved by ambulatory compared with office blood pressure.
Hermida RC, Ayala DE, Mojón A, Smolensky MH, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, Salgado JL, Durán C, Sánchez JJ, Fernández JR. Hermida RC, et al. Among authors: crespo jj. Rev Esp Cardiol (Engl Ed). 2021 Nov;74(11):953-961. doi: 10.1016/j.rec.2020.08.004. Epub 2020 Sep 16. Rev Esp Cardiol (Engl Ed). 2021. PMID: 32950423 English, Spanish.
Does Timing of Antihypertensive Medication Dosing Matter?
Hermida RC, Hermida-Ayala RG, Smolensky MH, Mojón A, Crespo JJ, Otero A, Ríos MT, Domínguez-Sardiña M, Fernández JR. Hermida RC, et al. Among authors: crespo jj. Curr Cardiol Rep. 2020 Aug 9;22(10):118. doi: 10.1007/s11886-020-01353-7. Curr Cardiol Rep. 2020. PMID: 32772186 Review.
Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials.
Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Mojón A, Fernández JR, Hermida RC. Crespo JJ, et al. Chronobiol Int. 2020 May;37(5):771-780. doi: 10.1080/07420528.2020.1781351. Epub 2020 Jul 20. Chronobiol Int. 2020. PMID: 32684071
The Hygia Project and Hygia Chronotherapy Trial: insights of we clinical investigators on the impact of the embedded continuing medical education on primary-care practice and improved patient cardiovascular health.
Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ. Crespo JJ, et al. Chronobiol Int. 2020 May;37(5):759-766. doi: 10.1080/07420528.2020.1771357. Epub 2020 Jul 20. Chronobiol Int. 2020. PMID: 32684006
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