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AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.
Marino M, Zhou L, Rincon MY, Callaerts-Vegh Z, Verhaert J, Wahis J, Creemers E, Yshii L, Wierda K, Saito T, Marneffe C, Voytyuk I, Wouters Y, Dewilde M, Duqué SI, Vincke C, Levites Y, Golde TE, Saido TC, Muyldermans S, Liston A, De Strooper B, Holt MG. Marino M, et al. Among authors: creemers e. EMBO Mol Med. 2022 Apr 7;14(4):e09824. doi: 10.15252/emmm.201809824. Epub 2022 Mar 30. EMBO Mol Med. 2022. PMID: 35352880 Free PMC article.
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.
Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J. Rice HC, et al. Among authors: creemers e. Science. 2019 Jan 11;363(6423):eaao4827. doi: 10.1126/science.aao4827. Science. 2019. PMID: 30630900 Free PMC article.
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, Uytterhoeven V, Verstreken P. Largo-Barrientos P, et al. Among authors: creemers e. Neuron. 2021 Mar 3;109(5):767-777.e5. doi: 10.1016/j.neuron.2020.12.016. Epub 2021 Jan 19. Neuron. 2021. PMID: 33472038 Free PMC article.
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.
Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, Dooley J, Kouser L, Verschoren S, Lagou V, Kemps H, Gervois P, de Boer A, Burton OT, Wahis J, Verhaert J, Tareen SHK, Roca CP, Singh K, Whyte CE, Kerstens A, Callaerts-Vegh Z, Poovathingal S, Prezzemolo T, Wierda K, Dashwood A, Xie J, Van Wonterghem E, Creemers E, Aloulou M, Gsell W, Abiega O, Munck S, Vandenbroucke RE, Bronckaers A, Lemmens R, De Strooper B, Van Den Bosch L, Himmelreich U, Fitzsimons CP, Holt MG, Liston A. Yshii L, et al. Among authors: creemers e. Nat Immunol. 2022 Jun;23(6):878-891. doi: 10.1038/s41590-022-01208-z. Epub 2022 May 26. Nat Immunol. 2022. PMID: 35618831 Free PMC article.
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.
Calafate S, Özturan G, Thrupp N, Vanderlinden J, Santa-Marinha L, Morais-Ribeiro R, Ruggiero A, Bozic I, Rusterholz T, Lorente-Echeverría B, Dias M, Chen WT, Fiers M, Lu A, Vlaeminck I, Creemers E, Craessaerts K, Vandenbempt J, van Boekholdt L, Poovathingal S, Davie K, Thal DR, Wierda K, Oliveira TG, Slutsky I, Adamantidis A, De Strooper B, de Wit J. Calafate S, et al. Among authors: creemers e. Nat Neurosci. 2023 Jun;26(6):1021-1031. doi: 10.1038/s41593-023-01325-4. Epub 2023 May 15. Nat Neurosci. 2023. PMID: 37188873 Free PMC article.
Mitochondria metabolism sets the species-specific tempo of neuronal development.
Iwata R, Casimir P, Erkol E, Boubakar L, Planque M, Gallego López IM, Ditkowska M, Gaspariunaite V, Beckers S, Remans D, Vints K, Vandekeere A, Poovathingal S, Bird M, Vlaeminck I, Creemers E, Wierda K, Corthout N, Vermeersch P, Carpentier S, Davie K, Mazzone M, Gounko NV, Aerts S, Ghesquière B, Fendt SM, Vanderhaeghen P. Iwata R, et al. Among authors: creemers e. Science. 2023 Feb 10;379(6632):eabn4705. doi: 10.1126/science.abn4705. Epub 2023 Feb 10. Science. 2023. PMID: 36705539
Quaking regulates circular RNA production in cardiomyocytes.
Montañés-Agudo P, van der Made I, Aufiero S, Tijsen AJ, Pinto YM, Creemers EE. Montañés-Agudo P, et al. Among authors: creemers ee. J Cell Sci. 2023 Jul 1;136(13):jcs261120. doi: 10.1242/jcs.261120. Epub 2023 Jun 30. J Cell Sci. 2023. PMID: 37272356 Free PMC article.
Splicing factors in the heart: Uncovering shared and unique targets.
Montañés-Agudo P, Pinto YM, Creemers EE. Montañés-Agudo P, et al. Among authors: creemers ee. J Mol Cell Cardiol. 2023 Jun;179:72-79. doi: 10.1016/j.yjmcc.2023.04.003. Epub 2023 Apr 13. J Mol Cell Cardiol. 2023. PMID: 37059416 Free article.
The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes.
Montañés-Agudo P, Aufiero S, Schepers EN, van der Made I, Cócera-Ortega L, Ernault AC, Richard S, Kuster DWD, Christoffels VM, Pinto YM, Creemers EE. Montañés-Agudo P, et al. Among authors: creemers ee. Cardiovasc Res. 2023 May 22;119(5):1161-1174. doi: 10.1093/cvr/cvad007. Cardiovasc Res. 2023. PMID: 36627242 Free PMC article.
163 results