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3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.
Xue L, Shi DH, Harjani JR, Huang F, Beveridge JG, Dingjan T, Ban K, Diab S, Duffy S, Lucantoni L, Fletcher S, Chiu FCK, Blundell S, Ellis K, Ralph SA, Wirjanata G, Teguh S, Noviyanti R, Chavchich M, Creek D, Price RN, Marfurt J, Charman SA, Cuellar ME, Strasser JM, Dahlin JL, Walters MA, Edstein MD, Avery VM, Baell JB. Xue L, et al. Among authors: creek d. J Med Chem. 2019 Mar 14;62(5):2485-2498. doi: 10.1021/acs.jmedchem.8b01799. Epub 2019 Mar 5. J Med Chem. 2019. PMID: 30715882
Stability of peroxide antimalarials in the presence of human hemoglobin.
Creek DJ, Ryan E, Charman WN, Chiu FC, Prankerd RJ, Vennerstrom JL, Charman SA. Creek DJ, et al. Antimicrob Agents Chemother. 2009 Aug;53(8):3496-500. doi: 10.1128/AAC.00363-09. Epub 2009 Jun 1. Antimicrob Agents Chemother. 2009. PMID: 19487440 Free PMC article.
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
Wang X, Creek DJ, Schiaffo CE, Dong Y, Chollet J, Scheurer C, Wittlin S, Charman SA, Dussault PH, Wood JK, Vennerstrom JL. Wang X, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4542-5. doi: 10.1016/j.bmcl.2009.07.013. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19616946
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL. Dong Y, et al. J Med Chem. 2010 Jan 14;53(1):481-91. doi: 10.1021/jm901473s. J Med Chem. 2010. PMID: 19924861
160 results