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Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.
Brewitz L, Dumjahn L, Zhao Y, Owen CD, Laidlaw SM, Malla TR, Nguyen D, Lukacik P, Salah E, Crawshaw AD, Warren AJ, Trincao J, Strain-Damerell C, Carroll MW, Walsh MA, Schofield CJ. Brewitz L, et al. Among authors: crawshaw ad. J Med Chem. 2023 Feb 23;66(4):2663-2680. doi: 10.1021/acs.jmedchem.2c01627. Epub 2023 Feb 9. J Med Chem. 2023. PMID: 36757959 Free PMC article.
Measuring energy-dependent photoelectron escape in microcrystals.
Storm SLS, Crawshaw AD, Devenish NE, Bolton R, Hall DR, Tews I, Evans G. Storm SLS, et al. Among authors: crawshaw ad. IUCrJ. 2020 Jan 1;7(Pt 1):129-135. doi: 10.1107/S2052252519016178. eCollection 2020 Jan 1. IUCrJ. 2020. PMID: 31949913 Free PMC article.
In vacuo X-ray data collection from graphene-wrapped protein crystals.
Warren AJ, Crawshaw AD, Trincao J, Aller P, Alcock S, Nistea I, Salgado PS, Evans G. Warren AJ, et al. Among authors: crawshaw ad. Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2079-88. doi: 10.1107/S1399004715014194. Epub 2015 Sep 26. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26457431 Free PMC article.
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