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Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities.
Zhang Y, Remillard D, Onubogu U, Karakyriakou B, Asiaban JN, Ramos AR, Bowland K, Bishop TR, Barta PA, Nance S, Durbin AD, Ott CJ, Janiszewska M, Cravatt BF, Erb MA. Zhang Y, et al. Among authors: cravatt bf. Nat Struct Mol Biol. 2023 Aug;30(8):1160-1171. doi: 10.1038/s41594-023-01041-4. Epub 2023 Jul 24. Nat Struct Mol Biol. 2023. PMID: 37488358 Free PMC article.
The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids.
Akefe IO, Saber SH, Matthews B, Venkatesh BG, Gormal RS, Blackmore DG, Alexander S, Sieriecki E, Gambin Y, Bertran-Gonzalez J, Vitale N, Humeau Y, Gaudin A, Ellis SA, Michaels AA, Xue M, Cravatt B, Joensuu M, Wallis TP, Meunier FA. Akefe IO, et al. EMBO J. 2024 Feb;43(4):533-567. doi: 10.1038/s44318-024-00030-7. Epub 2024 Feb 5. EMBO J. 2024. PMID: 38316990 Free PMC article.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, MacRae NS, DeMeester KE, Njomen E, Hargis LM, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. Among authors: cravatt bf. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.586158. doi: 10.1101/2024.03.21.586158. bioRxiv. 2024. PMID: 38562719 Free PMC article. Preprint.
573 results