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Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations.
Le Dour C, Chatzifrangkeskou M, Macquart C, Magiera MM, Peccate C, Jouve C, Virtanen L, Heliö T, Aalto-Setälä K, Crasto S, Cadot B, Cardoso D, Mougenot N, Adesse D, Di Pasquale E, Hulot JS, Taimen P, Janke C, Muchir A. Le Dour C, et al. Among authors: crasto s. Nat Commun. 2022 Dec 22;13(1):7886. doi: 10.1038/s41467-022-35639-x. Nat Commun. 2022. PMID: 36550158 Free PMC article.
Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation.
Chatzifrangkeskou M, Yadin D, Marais T, Chardonnet S, Cohen-Tannoudji M, Mougenot N, Schmitt A, Crasto S, Di Pasquale E, Macquart C, Tanguy Y, Jebeniani I, Pucéat M, Morales Rodriguez B, Goldmann WH, Dal Ferro M, Biferi MG, Knaus P, Bonne G, Worman HJ, Muchir A. Chatzifrangkeskou M, et al. Among authors: crasto s. Hum Mol Genet. 2018 Sep 1;27(17):3060-3078. doi: 10.1093/hmg/ddy215. Hum Mol Genet. 2018. PMID: 29878125 Free PMC article.
The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy.
Salvarani N, Crasto S, Miragoli M, Bertero A, Paulis M, Kunderfranco P, Serio S, Forni A, Lucarelli C, Dal Ferro M, Larcher V, Sinagra G, Vezzoni P, Murry CE, Faggian G, Condorelli G, Di Pasquale E. Salvarani N, et al. Among authors: crasto s. Nat Commun. 2019 May 22;10(1):2267. doi: 10.1038/s41467-019-09929-w. Nat Commun. 2019. PMID: 31118417 Free PMC article.
Generation of two iPSC lines (FAMRCi007-A and FAMRCi007-B) from patient with Emery-Dreifuss muscular dystrophy and heart rhythm abnormalities carrying genetic variant LMNA p.Arg249Gln.
Perepelina K, Kostina A, Klauzen P, Khudiakov A, Rabino M, Crasto S, Zlotina A, Fomicheva Y, Sergushichev A, Oganesian M, Dmitriev A, Kostareva A, Di Pasquale E, Malashicheva A. Perepelina K, et al. Among authors: crasto s. Stem Cell Res. 2020 Jun 29;47:101895. doi: 10.1016/j.scr.2020.101895. Online ahead of print. Stem Cell Res. 2020. PMID: 32659731 Free article.
Divergent Transcription of the Nkx2-5 Locus Generates Two Enhancer RNAs with Opposing Functions.
Salamon I, Serio S, Bianco S, Pagiatakis C, Crasto S, Chiariello AM, Conte M, Cattaneo P, Fiorillo L, Felicetta A, di Pasquale E, Kunderfranco P, Nicodemi M, Papait R, Condorelli G. Salamon I, et al. Among authors: crasto s. iScience. 2020 Sep 6;23(9):101539. doi: 10.1016/j.isci.2020.101539. eCollection 2020 Sep 25. iScience. 2020. PMID: 33083767 Free PMC article.
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