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The t6A modification acts as a positive determinant for the anticodon nuclease PrrC, and is distinctively nonessential in Streptococcus mutans.
Bacusmo JM, Orsini SS, Hu J, DeMott M, Thiaville PC, Elfarash A, Paulines MJ, Rojas-Benítez D, Meineke B, Deutsch C, Iwata-Reuyl D, Limbach PA, Dedon PC, Rice KC, Shuman S, Crécy-Lagard V. Bacusmo JM, et al. RNA Biol. 2018;15(4-5):508-517. doi: 10.1080/15476286.2017.1353861. Epub 2017 Sep 13. RNA Biol. 2018. PMID: 28726545 Free PMC article.
Experimental evolution of a facultative thermophile from a mesophilic ancestor.
Blaby IK, Lyons BJ, Wroclawska-Hughes E, Phillips GC, Pyle TP, Chamberlin SG, Benner SA, Lyons TJ, Crécy-Lagard Vd, Crécy Ed. Blaby IK, et al. Appl Environ Microbiol. 2012 Jan;78(1):144-55. doi: 10.1128/AEM.05773-11. Epub 2011 Oct 21. Appl Environ Microbiol. 2012. PMID: 22020511 Free PMC article.
Functional redundancy in tRNA dihydrouridylation.
Sudol C, Kilz LM, Marchand V, Thullier Q, Guérineau V, Goyenvalle C, Faivre B, Toubdji S, Lombard M, Jean-Jean O, de Crécy-Lagard V, Helm M, Motorin Y, Brégeon D, Hamdane D. Sudol C, et al. Among authors: de crecy lagard v. Nucleic Acids Res. 2024 Apr 29:gkae325. doi: 10.1093/nar/gkae325. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38682613
Alternate routes to mnm5s2U synthesis in Gram-positive bacteria.
Jaroch M, Sun G, Tsui H-CT, Reed C, Sun J, Jörg M, Winkler ME, Rice KC, Dziergowska A, Stich TA, Dedon PC, Dos Santos PC, de Crécy-Lagard V. Jaroch M, et al. Among authors: de crecy lagard v. J Bacteriol. 2024 Apr 18;206(4):e0045223. doi: 10.1128/jb.00452-23. Epub 2024 Mar 29. J Bacteriol. 2024. PMID: 38551342 Free PMC article.
191 results