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Page 1
Sodium channels and pain.
Habib AM, Wood JN, Cox JJ. Habib AM, et al. Among authors: cox jj. Handb Exp Pharmacol. 2015;227:39-56. doi: 10.1007/978-3-662-46450-2_3. Handb Exp Pharmacol. 2015. PMID: 25846613 Review.
The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation.
Deuis JR, Ragnarsson L, Robinson SD, Dekan Z, Chan L, Jin AH, Tran P, McMahon KL, Li S, Wood JN, Cox JJ, King GF, Herzig V, Vetter I. Deuis JR, et al. Among authors: cox jj. Front Pharmacol. 2022 Jan 14;12:789570. doi: 10.3389/fphar.2021.789570. eCollection 2021. Front Pharmacol. 2022. PMID: 35095499 Free PMC article.
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.
Jami S, Deuis JR, Klasfauseweh T, Cheng X, Kurdyukov S, Chung F, Okorokov AL, Li S, Zhang J, Cristofori-Armstrong B, Israel MR, Ju RJ, Robinson SD, Zhao P, Ragnarsson L, Andersson Å, Tran P, Schendel V, McMahon KL, Tran HNT, Chin YK, Zhu Y, Liu J, Crawford T, Purushothamvasan S, Habib AM, Andersson DA, Rash LD, Wood JN, Zhao J, Stehbens SJ, Mobli M, Leffler A, Jiang D, Cox JJ, Waxman SG, Dib-Hajj SD, Neely GG, Durek T, Vetter I. Jami S, et al. Among authors: cox jj. Nat Commun. 2023 Apr 28;14(1):2442. doi: 10.1038/s41467-023-37963-2. Nat Commun. 2023. PMID: 37117223 Free PMC article.
Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia.
Cregg R, Laguda B, Werdehausen R, Cox JJ, Linley JE, Ramirez JD, Bodi I, Markiewicz M, Howell KJ, Chen YC, Agnew K, Houlden H, Lunn MP, Bennett DL, Wood JN, Kinali M. Cregg R, et al. Among authors: cox jj. Neuromolecular Med. 2013 Jun;15(2):265-78. doi: 10.1007/s12017-012-8216-8. Epub 2013 Jan 6. Neuromolecular Med. 2013. PMID: 23292638 Free PMC article.
No pain, more gain.
Cox JJ, Wood JN. Cox JJ, et al. Nat Genet. 2013 Nov;45(11):1271-2. doi: 10.1038/ng.2810. Nat Genet. 2013. PMID: 24165728
Sensory neuron-derived NaV1.7 contributes to dorsal horn neuron excitability.
Alles SRA, Nascimento F, Luján R, Luiz AP, Millet Q, Bangash MA, Santana-Varela S, Zhou X, Cox JJ, Okorokov AL, Beato M, Zhao J, Wood JN. Alles SRA, et al. Among authors: cox jj. Sci Adv. 2020 Feb 19;6(8):eaax4568. doi: 10.1126/sciadv.aax4568. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32128393 Free PMC article.
A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7.
MacDonald DI, Sikandar S, Weiss J, Pyrski M, Luiz AP, Millet Q, Emery EC, Mancini F, Iannetti GD, Alles SRA, Arcangeletti M, Zhao J, Cox JJ, Brownstone RM, Zufall F, Wood JN. MacDonald DI, et al. Among authors: cox jj. Neuron. 2021 May 5;109(9):1497-1512.e6. doi: 10.1016/j.neuron.2021.03.012. Epub 2021 Apr 5. Neuron. 2021. PMID: 33823138 Free PMC article.
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