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Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study.
El-Sayed S, Metwally K, El-Shanawani AA, Abdel-Aziz LM, El-Rashedy AA, Soliman MES, Quattrini L, Coviello V, la Motta C. El-Sayed S, et al. Among authors: coviello v. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4760-4764. doi: 10.1016/j.bmcl.2017.08.050. Epub 2017 Aug 24. Bioorg Med Chem Lett. 2017. PMID: 28935265
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.
Coviello V, Marchi B, Sartini S, Quattrini L, Marini AM, Simorini F, Taliani S, Salerno S, Orlandi P, Fioravanti A, Desidero TD, Vullo D, Da Settimo F, Supuran CT, Bocci G, La Motta C. Coviello V, et al. J Med Chem. 2016 Jul 14;59(13):6547-52. doi: 10.1021/acs.jmedchem.6b00616. Epub 2016 Jun 27. J Med Chem. 2016. PMID: 27305384
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.
La Pietra V, Sartini S, Botta L, Antonelli A, Ferrari SM, Fallahi P, Moriconi A, Coviello V, Quattrini L, Ke YY, Hsing-Pang H, Da Settimo F, Novellino E, La Motta C, Marinelli L. La Pietra V, et al. Among authors: coviello v. Eur J Med Chem. 2018 Apr 25;150:491-505. doi: 10.1016/j.ejmech.2018.02.080. Epub 2018 Mar 2. Eur J Med Chem. 2018. PMID: 29549836
Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.
Sartini S, Coviello V, Bruno A, La Pietra V, Marinelli L, Simorini F, Taliani S, Salerno S, Marini AM, Fioravanti A, Orlandi P, Antonelli A, Da Settimo F, Novellino E, Bocci G, La Motta C. Sartini S, et al. Among authors: coviello v. J Med Chem. 2014 Feb 27;57(4):1225-35. doi: 10.1021/jm401358b. Epub 2014 Feb 5. J Med Chem. 2014. PMID: 24447248
51 results