Coulombe R - Search Results

1

Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.

LaPlante SR, Carson R, Gillard J, Aubry N, Coulombe R, Bordeleau S, Bonneau P, Little M, O'Meara J, Beaulieu PL. LaPlante SR, et al. Among authors: coulombe r. J Med Chem. 2013 Jun 27;56(12):5142-50. doi: 10.1021/jm400535b. Epub 2013 Jun 13. J Med Chem. 2013. PMID: 23730910

2

N- versus O-alkylation: utilizing NMR methods to establish reliable primary structure determinations for drug discovery.

LaPlante SR, Bilodeau F, Aubry N, Gillard JR, O'Meara J, Coulombe R. LaPlante SR, et al. Among authors: coulombe r. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4663-8. doi: 10.1016/j.bmcl.2013.06.007. Epub 2013 Jun 12. Bioorg Med Chem Lett. 2013. PMID: 23809849

3

Monitoring drug self-aggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy.

LaPlante SR, Aubry N, Bolger G, Bonneau P, Carson R, Coulombe R, Sturino C, Beaulieu PL. LaPlante SR, et al. Among authors: coulombe r. J Med Chem. 2013 Sep 12;56(17):7073-83. doi: 10.1021/jm4008714. Epub 2013 Aug 22. J Med Chem. 2013. PMID: 23919803

4

Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.

LaPlante SR, Forgione P, Boucher C, Coulombe R, Gillard J, Hucke O, Jakalian A, Joly MA, Kukolj G, Lemke C, McCollum R, Titolo S, Beaulieu PL, Stammers T. LaPlante SR, et al. Among authors: coulombe r. J Med Chem. 2014 Mar 13;57(5):1944-51. doi: 10.1021/jm401202a. Epub 2013 Sep 30. J Med Chem. 2014. PMID: 24024973

5

Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).

LaPlante SR, Bös M, Brochu C, Chabot C, Coulombe R, Gillard JR, Jakalian A, Poirier M, Rancourt J, Stammers T, Thavonekham B, Beaulieu PL, Kukolj G, Tsantrizos YS. LaPlante SR, et al. Among authors: coulombe r. J Med Chem. 2014 Mar 13;57(5):1845-54. doi: 10.1021/jm4011862. Epub 2013 Nov 11. J Med Chem. 2014. PMID: 24159919

6

Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.

LaPlante SR, Padyana AK, Abeywardane A, Bonneau P, Cartier M, Coulombe R, Jakalian A, Wildeson-Jones J, Li X, Liang S, McKercher G, White P, Zhang Q, Taylor SJ. LaPlante SR, et al. Among authors: coulombe r. J Med Chem. 2014 Mar 13;57(5):2074-90. doi: 10.1021/jm401432c. Epub 2014 Jan 27. J Med Chem. 2014. PMID: 24467709

7

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

O'Meara JA, Jakalian A, LaPlante S, Bonneau PR, Coulombe R, Faucher AM, Guse I, Landry S, Racine J, Simoneau B, Thavonekham B, Yoakim C. O'Meara JA, et al. Among authors: coulombe r. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3362-6. doi: 10.1016/j.bmcl.2007.03.097. Epub 2007 Apr 5. Bioorg Med Chem Lett. 2007. PMID: 17451954

8

N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

Beaulieu PL, Jolicoeur E, Gillard J, Brochu C, Coulombe R, Dansereau N, Duan J, Garneau M, Jakalian A, Kühn P, Lagacé L, LaPlante S, McKercher G, Perrault S, Poirier M, Poupart MA, Stammers T, Thauvette L, Thavonekham B, Kukolj G. Beaulieu PL, et al. Among authors: coulombe r. Bioorg Med Chem Lett. 2010 Feb 1;20(3):857-61. doi: 10.1016/j.bmcl.2009.12.101. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20074949

9

Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.

LaPlante SR, Gillard JR, Jakalian A, Aubry N, Coulombe R, Brochu C, Tsantrizos YS, Poirier M, Kukolj G, Beaulieu PL. LaPlante SR, et al. Among authors: coulombe r. J Am Chem Soc. 2010 Nov 3;132(43):15204-12. doi: 10.1021/ja101358s. J Am Chem Soc. 2010. PMID: 20942454

10

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

Fader LD, Bethell R, Bonneau P, Bös M, Bousquet Y, Cordingley MG, Coulombe R, Deroy P, Faucher AM, Gagnon A, Goudreau N, Grand-Maître C, Guse I, Hucke O, Kawai SH, Lacoste JE, Landry S, Lemke CT, Malenfant E, Mason S, Morin S, O'Meara J, Simoneau B, Titolo S, Yoakim C. Fader LD, et al. Among authors: coulombe r. Bioorg Med Chem Lett. 2011 Jan 1;21(1):398-404. doi: 10.1016/j.bmcl.2010.10.131. Epub 2010 Oct 31. Bioorg Med Chem Lett. 2011. PMID: 21087861

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