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Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM. Takarada JE, et al. Among authors: counago rm. Bioorg Med Chem. 2024 Jan 15;98:117561. doi: 10.1016/j.bmc.2023.117561. Epub 2023 Dec 20. Bioorg Med Chem. 2024. PMID: 38157838 Free article.
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Segretti ND, Takarada JE, Ferreira MA Jr, da Silva Santiago A, Teodoro BVM, Damião MCFCB, Godoi PH, Cunha MR, Fala AM, Ramos PZ, Ishikawa EE, Mascarello A, Serafim RAM, Azevedo H, Guimarães CRW, Couñago RM. Segretti ND, et al. Among authors: counago rm. Bioorg Med Chem Lett. 2022 Jul 15;68:128764. doi: 10.1016/j.bmcl.2022.128764. Epub 2022 May 2. Bioorg Med Chem Lett. 2022. PMID: 35504513
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
Serafim RAM, de Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM. Serafim RAM, et al. Among authors: counago rm. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271. doi: 10.1021/acsmedchemlett.9b00082. eCollection 2019 Sep 12. ACS Med Chem Lett. 2019. PMID: 31531195 Free PMC article.
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.
Profeta GS, Dos Reis CV, Santiago ADS, Godoi PHC, Fala AM, Wells CI, Sartori R, Salmazo APT, Ramos PZ, Massirer KB, Elkins JM, Drewry DH, Gileadi O, Couñago RM. Profeta GS, et al. Among authors: counago rm. Sci Rep. 2019 Nov 11;9(1):16452. doi: 10.1038/s41598-019-52795-1. Sci Rep. 2019. PMID: 31712618 Free PMC article.
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
M Serafim RA, da Silva Santiago A, Schwalm MP, Hu Z, Dos Reis CV, Takarada JE, Mezzomo P, Massirer KB, Kudolo M, Gerstenecker S, Chaikuad A, Zender L, Knapp S, Laufer S, Couñago RM, Gehringer M. M Serafim RA, et al. Among authors: counago rm. J Med Chem. 2022 Feb 24;65(4):3173-3192. doi: 10.1021/acs.jmedchem.1c01165. Epub 2022 Feb 15. J Med Chem. 2022. PMID: 35167750
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.
Silva SF, Klippel AH, Ramos PZ, Santiago ADS, Valentini SR, Bengtson MH, Massirer KB, Bilsland E, Couñago RM, Zanelli CF. Silva SF, et al. Among authors: counago rm. PLoS Negl Trop Dis. 2020 Oct 12;14(10):e0008762. doi: 10.1371/journal.pntd.0008762. eCollection 2020 Oct. PLoS Negl Trop Dis. 2020. PMID: 33044977 Free PMC article.
44 results