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Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.
Lupien M, Jeyakumar M, Hébert E, Hilmi K, Cotnoir-White D, Loch C, Auger A, Dayan G, Pinard GA, Wurtz JM, Moras D, Katzenellenbogen J, Mader S. Lupien M, et al. Among authors: cotnoir white d. Mol Endocrinol. 2007 Apr;21(4):797-816. doi: 10.1210/me.2006-0074. Epub 2007 Feb 13. Mol Endocrinol. 2007. PMID: 17299137
Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat.
Barrett RRG, Nash C, Diennet M, Cotnoir-White D, Doyle C, Mader S, Thomson AA, Gleason JL. Barrett RRG, et al. Among authors: cotnoir white d. Bioorg Med Chem Lett. 2022 Jan 1;55:128441. doi: 10.1016/j.bmcl.2021.128441. Epub 2021 Nov 9. Bioorg Med Chem Lett. 2022. PMID: 34767912