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Programming inactive RNA-binding small molecules into bioactive degraders.
Tong Y, Lee Y, Liu X, Childs-Disney JL, Suresh BM, Benhamou RI, Yang C, Li W, Costales MG, Haniff HS, Sievers S, Abegg D, Wegner T, Paulisch TO, Lekah E, Grefe M, Crynen G, Van Meter M, Wang T, Gibaut QMR, Cleveland JL, Adibekian A, Glorius F, Waldmann H, Disney MD. Tong Y, et al. Among authors: costales mg. Nature. 2023 Jun;618(7963):169-179. doi: 10.1038/s41586-023-06091-8. Epub 2023 May 24. Nature. 2023. PMID: 37225982 Free PMC article.
How We Think about Targeting RNA with Small Molecules.
Costales MG, Childs-Disney JL, Haniff HS, Disney MD. Costales MG, et al. J Med Chem. 2020 Sep 10;63(17):8880-8900. doi: 10.1021/acs.jmedchem.9b01927. Epub 2020 Mar 26. J Med Chem. 2020. PMID: 32212706 Free PMC article.
Small Molecule Targeted Recruitment of a Nuclease to RNA.
Costales MG, Matsumoto Y, Velagapudi SP, Disney MD. Costales MG, et al. J Am Chem Soc. 2018 Jun 6;140(22):6741-6744. doi: 10.1021/jacs.8b01233. Epub 2018 May 24. J Am Chem Soc. 2018. PMID: 29792692 Free PMC article.
Adding Broccoli to the Biosensor Menu.
Costales MG, Disney MD. Costales MG, et al. Cell Chem Biol. 2019 Apr 18;26(4):463-465. doi: 10.1016/j.chembiol.2019.04.004. Cell Chem Biol. 2019. PMID: 31002799 Free article.
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.
Costales MG, Aikawa H, Li Y, Childs-Disney JL, Abegg D, Hoch DG, Pradeep Velagapudi S, Nakai Y, Khan T, Wang KW, Yildirim I, Adibekian A, Wang ET, Disney MD. Costales MG, et al. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2406-2411. doi: 10.1073/pnas.1914286117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964809 Free PMC article.
16 results