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Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models.
Costa-Machado LF, Garcia-Dominguez E, McIntyre RL, Lopez-Aceituno JL, Ballesteros-Gonzalez Á, Tapia-Gonzalez A, Fabregat-Safont D, Eisenberg T, Gomez J, Plaza A, Sierra-Ramirez A, Perez M, Villanueva-Bermejo D, Fornari T, Loza MI, Herradon G, Hofer SJ, Magnes C, Madeo F, Duerr JS, Pozo OJ, Galindo MI, Del Pino I, Houtkooper RH, Megias D, Viña J, Gomez-Cabrera MC, Fernandez-Marcos PJ. Costa-Machado LF, et al. Nat Commun. 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y. Nat Commun. 2023. PMID: 37188705 Free PMC article.
The sirtuin family in cancer.
Costa-Machado LF, Fernandez-Marcos PJ. Costa-Machado LF, et al. Cell Cycle. 2019 Sep;18(18):2164-2196. doi: 10.1080/15384101.2019.1634953. Epub 2019 Jul 25. Cell Cycle. 2019. PMID: 31251117 Free PMC article.
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.
Barradas M, Plaza A, Colmenarejo G, Lázaro I, Costa-Machado LF, Martín-Hernández R, Micó V, López-Aceituno JL, Herranz J, Pantoja C, Tejero H, Diaz-Ruiz A, Al-Shahrour F, Daimiel L, Loria-Kohen V, Ramirez de Molina A, Efeyan A, Serrano M, Pozo OJ, Sala-Vila A, Fernandez-Marcos PJ. Barradas M, et al. Among authors: costa machado lf. Nat Commun. 2022 Sep 27;13(1):5677. doi: 10.1038/s41467-022-33352-3. Nat Commun. 2022. PMID: 36167809 Free PMC article.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Costa-Machado LF, Martín-Hernández R, Sanchez-Luengo MÁ, Hess K, Vales-Villamarin C, Barradas M, Lynch C, de la Nava D, Diaz-Ruiz A, de Cabo R, Cañamero M, Martinez L, Sanchez-Carbayo M, Herranz D, Serrano M, Fernandez-Marcos PJ. Costa-Machado LF, et al. EMBO Rep. 2018 Sep;19(9):e43879. doi: 10.15252/embr.201643879. Epub 2018 Jul 18. EMBO Rep. 2018. PMID: 30021836 Free PMC article.