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Neuroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastoma.
do Nascimento RP, Dos Santos BL, Amparo JAO, Soares JRP, da Silva KC, Santana MR, Almeida ÁMAN, da Silva VDA, Costa MFD, Ulrich H, Moura-Neto V, Lopes GPF, Costa SL. do Nascimento RP, et al. Among authors: costa mfd, costa sl. Pharmaceutics. 2022 Jan 4;14(1):116. doi: 10.3390/pharmaceutics14010116. Pharmaceutics. 2022. PMID: 35057010 Free PMC article. Review.
Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.
Santos BL, Oliveira MN, Coelho PL, Pitanga BP, da Silva AB, Adelita T, Silva VD, Costa Mde F, El-Bachá RS, Tardy M, Chneiweiss H, Junier MP, Moura-Neto V, Costa SL. Santos BL, et al. Among authors: costa sl, costa mde f. Chem Biol Interact. 2015 Dec 5;242:123-38. doi: 10.1016/j.cbi.2015.07.014. Epub 2015 Sep 25. Chem Biol Interact. 2015. PMID: 26408079
The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, Fève M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP, Chneiweiss H. Assad Kahn S, et al. Among authors: costa sl. EMBO Mol Med. 2016 May 2;8(5):511-26. doi: 10.15252/emmm.201505421. Print 2016 May. EMBO Mol Med. 2016. PMID: 27138566 Free PMC article.
Specific Cytostatic and Cytotoxic Effect of Dihydrochelerythrine in Glioblastoma Cells: Role of NF-κB/β-catenin and STAT3/IL-6 Pathways.
Silva TCC, de Faria Lopes GP, de J Menezes-Filho N, de Oliveira DM, Pereira E, Pitanga BPS, Dos Santos Costa R, da Silva Velozo E, Freire SM, Clarêncio J, Borges HL, Rehen SK, Moura-Neto V, Costa SL. Silva TCC, et al. Among authors: costa sl. Anticancer Agents Med Chem. 2018;18(10):1386-1393. doi: 10.2174/1871520618666180412122101. Anticancer Agents Med Chem. 2018. PMID: 29651966
JM-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson's disease.
Fonseca-Fonseca LA, Wong-Guerra M, Ramírez-Sánchez J, Montano-Peguero Y, Padrón Yaquis AS, Rodríguez AM, da Silva VDA, Costa SL, Pardo-Andreu GL, Núñez-Figueredo Y. Fonseca-Fonseca LA, et al. Among authors: costa sl. Neurosci Lett. 2019 Jan 18;690:29-35. doi: 10.1016/j.neulet.2018.10.008. Epub 2018 Oct 7. Neurosci Lett. 2019. PMID: 30304707
Alkene lactones from Persea fulva (Lauraceae): Evaluation of their effects on tumor cell growth in vitro and molecular docking studies.
Reis IMA, Conceição RS, Ferreira RS, Dos Santos CC, da Silva GR, de Mattos Oliveira L, Cassiano DSA, Dos Santos Junior MC, Botura MB, da Silva VDA, Costa SL, da Silva TMS, Vieira IJC, Braz-Filho R, Branco A. Reis IMA, et al. Among authors: costa sl. Bioorg Chem. 2019 May;86:665-673. doi: 10.1016/j.bioorg.2019.02.023. Epub 2019 Feb 14. Bioorg Chem. 2019. PMID: 30826627
Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors.
Oliveira-Junior MS, Pereira EP, de Amorim VCM, Reis LTC, do Nascimento RP, da Silva VDA, Costa SL. Oliveira-Junior MS, et al. Among authors: costa sl. Int Immunopharmacol. 2019 May;70:302-312. doi: 10.1016/j.intimp.2019.02.055. Epub 2019 Mar 7. Int Immunopharmacol. 2019. PMID: 30852286 Free article.
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: costa sl. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805
127 results