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JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y. Fonseca-Fonseca LA, et al. Among authors: costa sl. Neurotoxicology. 2021 Jan;82:89-98. doi: 10.1016/j.neuro.2020.11.005. Epub 2020 Nov 21. Neurotoxicology. 2021. PMID: 33232743 Free article.
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Among authors: costa sl. Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19. Neuropharmacology. 2014. PMID: 24953828
Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.
de Araújo FM, Ferreira RS, Souza CS, Dos Santos CC, Rodrigues TLRS, E Silva JHC, Gasparotto J, Gelain DP, El-Bachá RS, D Costa MF, Fonseca JCM, Segura-Aguilar J, Costa SL, Silva VDA. de Araújo FM, et al. Among authors: costa sl. Neurotoxicology. 2018 May;66:98-106. doi: 10.1016/j.neuro.2018.03.009. Epub 2018 Mar 26. Neurotoxicology. 2018. PMID: 29588162 Free article.
JM-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson's disease.
Fonseca-Fonseca LA, Wong-Guerra M, Ramírez-Sánchez J, Montano-Peguero Y, Padrón Yaquis AS, Rodríguez AM, da Silva VDA, Costa SL, Pardo-Andreu GL, Núñez-Figueredo Y. Fonseca-Fonseca LA, et al. Among authors: costa sl. Neurosci Lett. 2019 Jan 18;690:29-35. doi: 10.1016/j.neulet.2018.10.008. Epub 2018 Oct 7. Neurosci Lett. 2019. PMID: 30304707
Alkene lactones from Persea fulva (Lauraceae): Evaluation of their effects on tumor cell growth in vitro and molecular docking studies.
Reis IMA, Conceição RS, Ferreira RS, Dos Santos CC, da Silva GR, de Mattos Oliveira L, Cassiano DSA, Dos Santos Junior MC, Botura MB, da Silva VDA, Costa SL, da Silva TMS, Vieira IJC, Braz-Filho R, Branco A. Reis IMA, et al. Among authors: costa sl. Bioorg Chem. 2019 May;86:665-673. doi: 10.1016/j.bioorg.2019.02.023. Epub 2019 Feb 14. Bioorg Chem. 2019. PMID: 30826627
Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors.
Oliveira-Junior MS, Pereira EP, de Amorim VCM, Reis LTC, do Nascimento RP, da Silva VDA, Costa SL. Oliveira-Junior MS, et al. Among authors: costa sl. Int Immunopharmacol. 2019 May;70:302-312. doi: 10.1016/j.intimp.2019.02.055. Epub 2019 Mar 7. Int Immunopharmacol. 2019. PMID: 30852286 Free article.
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: costa sl. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805
127 results