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New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line.
Amaral C, Varela C, Correia-da-Silva G, Tavares da Silva E, Carvalho RA, Costa SC, Cunha SC, Fernandes JO, Teixeira N, Roleira FM. Amaral C, et al. Among authors: costa sc. Biochimie. 2013 Nov;95(11):2097-106. doi: 10.1016/j.biochi.2013.07.023. Epub 2013 Aug 9. Biochimie. 2013. PMID: 23933094
Plant derived and dietary phenolic antioxidants: anticancer properties.
Roleira FM, Tavares-da-Silva EJ, Varela CL, Costa SC, Silva T, Garrido J, Borges F. Roleira FM, et al. Among authors: costa sc. Food Chem. 2015 Sep 15;183:235-58. doi: 10.1016/j.foodchem.2015.03.039. Epub 2015 Mar 18. Food Chem. 2015. PMID: 25863633 Review.
Exploring new chemical functionalities to improve aromatase inhibition of steroids.
Varela CL, Amaral C, Correia-da-Silva G, Costa SC, Carvalho RA, Costa G, Alcaro S, Teixeira NA, Tavares-da-Silva EJ, Roleira FM. Varela CL, et al. Among authors: costa g, costa sc. Bioorg Med Chem. 2016 Jun 15;24(12):2823-31. doi: 10.1016/j.bmc.2016.04.056. Epub 2016 Apr 26. Bioorg Med Chem. 2016. PMID: 27160054
C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships.
Roleira FMF, Varela C, Amaral C, Costa SC, Correia-da-Silva G, Moraca F, Costa G, Alcaro S, Teixeira NAA, Tavares da Silva EJ. Roleira FMF, et al. Among authors: costa g, costa sc. J Med Chem. 2019 Apr 11;62(7):3636-3657. doi: 10.1021/acs.jmedchem.9b00157. Epub 2019 Mar 26. J Med Chem. 2019. PMID: 30852901
Design, synthesis, and antitumor activity evaluation of steroidal oximes.
Gomes AR, Pires AS, Abrantes AM, Gonçalves AC, Costa SC, Varela CL, Silva ET, Botelho MF, Roleira FMF. Gomes AR, et al. Among authors: costa sc. Bioorg Med Chem. 2021 Sep 15;46:116360. doi: 10.1016/j.bmc.2021.116360. Epub 2021 Aug 8. Bioorg Med Chem. 2021. PMID: 34425478
Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7β substituted steroids.
Roleira FMF, Costa SC, Gomes AR, Varela CL, Amaral C, Augusto TV, Correia-da-Silva G, Romeo I, Costa G, Alcaro S, Teixeira N, Tavares-da-Silva EJ. Roleira FMF, et al. Among authors: costa g, costa sc. Bioorg Chem. 2023 Feb;131:106286. doi: 10.1016/j.bioorg.2022.106286. Epub 2022 Nov 23. Bioorg Chem. 2023. PMID: 36459778 Free article.
183 results