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Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.
Hohwieler M, Illing A, Hermann PC, Mayer T, Stockmann M, Perkhofer L, Eiseler T, Antony JS, Müller M, Renz S, Kuo CC, Lin Q, Sendler M, Breunig M, Kleiderman SM, Lechel A, Zenker M, Leichsenring M, Rosendahl J, Zenke M, Sainz B Jr, Mayerle J, Costa IG, Seufferlein T, Kormann M, Wagner M, Liebau S, Kleger A. Hohwieler M, et al. Among authors: costa ig. Gut. 2017 Mar;66(3):473-486. doi: 10.1136/gutjnl-2016-312423. Epub 2016 Sep 15. Gut. 2017. PMID: 27633923 Free PMC article.
Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma.
Sonntag R, Giebeler N, Nevzorova YA, Bangen JM, Fahrenkamp D, Lambertz D, Haas U, Hu W, Gassler N, Cubero FJ, Müller-Newen G, Abdallah AT, Weiskirchen R, Ticconi F, Costa IG, Barbacid M, Trautwein C, Liedtke C. Sonntag R, et al. Among authors: costa ig. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9282-9287. doi: 10.1073/pnas.1807155115. Epub 2018 Aug 27. Proc Natl Acad Sci U S A. 2018. PMID: 30150405 Free PMC article.
CXCR6 protects from inflammation and fibrosis in NEMOLPC-KO mice.
Liepelt A, Wehr A, Kohlhepp M, Mossanen JC, Kreggenwinkel K, Denecke B, Costa IG, Luedde T, Trautwein C, Tacke F. Liepelt A, et al. Among authors: costa ig. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):391-402. doi: 10.1016/j.bbadis.2018.11.020. Epub 2018 Nov 24. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30476545 Free article.
146 results