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Page 1
Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies.
Cosgun KN, Jumaa H, Robinson ME, Kistner KM, Xu L, Xiao G, Chan LN, Lee J, Kume K, Leveille E, Fonseca-Arce D, Khanduja D, Ng HL, Feldhahn N, Song J, Chan WC, Chen J, Taketo MM, Kothari S, Davids MS, Schjerven H, Jellusova J, Müschen M. Cosgun KN, et al. bioRxiv [Preprint]. 2023 Mar 15:2023.03.13.532152. doi: 10.1101/2023.03.13.532152. bioRxiv. 2023. PMID: 36993619 Free PMC article. Preprint.
Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling.
Lee J, Robinson ME, Sun R, Kume K, Ma N, Cosgun KN, Chan LN, Leveille E, Geng H, Vykunta VS, Shy BR, Marson A, Katz S, Chen J, Paietta E, Meffre E, Vaidehi N, Müschen M. Lee J, et al. Among authors: cosgun kn. bioRxiv [Preprint]. 2023 Mar 15:2023.03.13.532151. doi: 10.1101/2023.03.13.532151. bioRxiv. 2023. PMID: 36993276 Free PMC article. Preprint.
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Sadras T, Martin M, Kume K, Robinson ME, Saravanakumar S, Lenz G, Chen Z, Song JY, Siddiqi T, Oksa L, Knapp AM, Cutler J, Cosgun KN, Klemm L, Ecker V, Winchester J, Ghergus D, Soulas-Sprauel P, Kiefer F, Heisterkamp N, Pandey A, Ngo V, Wang L, Jumaa H, Buchner M, Ruland J, Chan WC, Meffre E, Martin T, Müschen M. Sadras T, et al. Among authors: cosgun kn. Mol Cell. 2021 May 20;81(10):2094-2111.e9. doi: 10.1016/j.molcel.2021.03.043. Epub 2021 Apr 19. Mol Cell. 2021. PMID: 33878293 Free PMC article.
Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. Lee J, et al. Among authors: cosgun kn. Nature. 2021 Apr;592(7852):E3. doi: 10.1038/s41586-021-03388-4. Nature. 2021. PMID: 33712811 No abstract available.
PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis.
Pan L, Hong C, Chan LN, Xiao G, Malvi P, Robinson ME, Geng H, Reddy ST, Lee J, Khairnar V, Cosgun KN, Xu L, Kume K, Sadras T, Wang S, Wajapeyee N, Müschen M. Pan L, et al. Among authors: cosgun kn. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2016553118. doi: 10.1073/pnas.2016553118. Proc Natl Acad Sci U S A. 2021. PMID: 33531346 Free PMC article.
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. Lee J, et al. Among authors: cosgun kn. Nature. 2020 Dec;588(7838):491-497. doi: 10.1038/s41586-020-2884-6. Epub 2020 Nov 4. Nature. 2020. PMID: 33149299 Free PMC article.
Signalling input from divergent pathways subverts B cell transformation.
Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. Chan LN, et al. Among authors: cosgun kn. Nature. 2020 Jul;583(7818):845-851. doi: 10.1038/s41586-020-2513-4. Epub 2020 Jul 22. Nature. 2020. PMID: 32699415 Free PMC article.
Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Chan LN, et al. Among authors: cosgun kn. Nature. 2018 Jun;558(7711):E5. doi: 10.1038/s41586-018-0164-5. Nature. 2018. PMID: 29849140
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. Xiao G, et al. Among authors: cosgun kn. Cell. 2018 Apr 5;173(2):470-484.e18. doi: 10.1016/j.cell.2018.02.048. Epub 2018 Mar 15. Cell. 2018. PMID: 29551267 Free PMC article.
Metabolic gatekeeper function of B-lymphoid transcription factors.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Chan LN, et al. Among authors: cosgun kn. Nature. 2017 Feb 23;542(7642):479-483. doi: 10.1038/nature21076. Epub 2017 Feb 13. Nature. 2017. PMID: 28192788 Free PMC article.
15 results