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Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.
Oshima M, Pechberty S, Bellini L, Göpel SO, Campana M, Rouch C, Dairou J, Cosentino C, Fantuzzi F, Toivonen S, Marchetti P, Magnan C, Cnop M, Le Stunff H, Scharfmann R. Oshima M, et al. Among authors: cosentino c. Diabetologia. 2020 Feb;63(2):395-409. doi: 10.1007/s00125-019-05046-x. Epub 2019 Dec 3. Diabetologia. 2020. PMID: 31796987 Free PMC article.
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.
Cosentino C, Toivonen S, Diaz Villamil E, Atta M, Ravanat JL, Demine S, Schiavo AA, Pachera N, Deglasse JP, Jonas JC, Balboa D, Otonkoski T, Pearson ER, Marchetti P, Eizirik DL, Cnop M, Igoillo-Esteve M. Cosentino C, et al. Nucleic Acids Res. 2018 Nov 2;46(19):10302-10318. doi: 10.1093/nar/gky839. Nucleic Acids Res. 2018. PMID: 30247717 Free PMC article.
DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.
Lytrivi M, Senée V, Salpea P, Fantuzzi F, Philippi A, Abdulkarim B, Sawatani T, Marín-Cañas S, Pachera N, Degavre A, Singh P, Derbois C, Lechner D, Ladrière L, Igoillo-Esteve M, Cosentino C, Marselli L, Deleuze JF, Marchetti P, Eizirik DL, Nicolino M, Chaussenot A, Julier C, Cnop M. Lytrivi M, et al. Among authors: cosentino c. Eur J Endocrinol. 2021 Mar;184(3):455-468. doi: 10.1530/EJE-20-0636. Eur J Endocrinol. 2021. PMID: 33486469
A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.
Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL. Alvelos MI, et al. Among authors: cosentino c. Islets. 2021 Jul 4;13(3-4):51-65. doi: 10.1080/19382014.2021.1948282. Epub 2021 Jul 9. Islets. 2021. PMID: 34241569 Free PMC article.
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M. Cunha DA, et al. Among authors: cosentino c. J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11. J Biol Chem. 2017. PMID: 28698383 Free PMC article.
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia.
Igoillo-Esteve M, Oliveira AF, Cosentino C, Fantuzzi F, Demarez C, Toivonen S, Hu A, Chintawar S, Lopes M, Pachera N, Cai Y, Abdulkarim B, Rai M, Marselli L, Marchetti P, Tariq M, Jonas JC, Boscolo M, Pandolfo M, Eizirik DL, Cnop M. Igoillo-Esteve M, et al. Among authors: cosentino c. JCI Insight. 2020 Jan 30;5(2):e134221. doi: 10.1172/jci.insight.134221. JCI Insight. 2020. PMID: 31877117 Free PMC article.
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.
De Franco E, Lytrivi M, Ibrahim H, Montaser H, Wakeling MN, Fantuzzi F, Patel K, Demarez C, Cai Y, Igoillo-Esteve M, Cosentino C, Lithovius V, Vihinen H, Jokitalo E, Laver TW, Johnson MB, Sawatani T, Shakeri H, Pachera N, Haliloglu B, Ozbek MN, Unal E, Yıldırım R, Godbole T, Yildiz M, Aydin B, Bilheu A, Suzuki I, Flanagan SE, Vanderhaeghen P, Senée V, Julier C, Marchetti P, Eizirik DL, Ellard S, Saarimäki-Vire J, Otonkoski T, Cnop M, Hattersley AT. De Franco E, et al. Among authors: cosentino c. J Clin Invest. 2020 Dec 1;130(12):6338-6353. doi: 10.1172/JCI141455. J Clin Invest. 2020. PMID: 33164986 Free PMC article.
294 results