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Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.
Sousa BB, de Almeida CR, Barahona AF, Lopes R, Martins-Logrado A, Cavaco M, Neves V, Carvalho LAR, Labão-Almeida C, Coelho AR, Leal Bento M, Lopes RMRM, Oliveira BL, Castanho MARB, Neumeister P, Deutsch A, Vladimer GI, Krall N, João C, Corzana F, Seixas JD, Fior R, Bernardes GJL. Sousa BB, et al. Among authors: corzana f. ACS Pharmacol Transl Sci. 2022 Nov 2;5(11):1156-1168. doi: 10.1021/acsptsci.2c00163. eCollection 2022 Nov 11. ACS Pharmacol Transl Sci. 2022. PMID: 36407952 Free PMC article.
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
Trastoy B, Du JJ, Cifuente JO, Rudolph L, García-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME. Trastoy B, et al. Among authors: corzana f. Nat Commun. 2023 Mar 27;14(1):1705. doi: 10.1038/s41467-023-37215-3. Nat Commun. 2023. PMID: 36973249 Free PMC article.
Turning universal O into rare Bombay type blood.
Anso I, Naegeli A, Cifuente JO, Orrantia A, Andersson E, Zenarruzabeitia O, Moraleda-Montoya A, García-Alija M, Corzana F, Del Orbe RA, Borrego F, Trastoy B, Sjögren J, Guerin ME. Anso I, et al. Among authors: corzana f. Nat Commun. 2023 Mar 30;14(1):1765. doi: 10.1038/s41467-023-37324-z. Nat Commun. 2023. PMID: 36997505 Free PMC article.
Lipoyl-Based Antagonists of Transient Receptor Potential Cation A (TRPA1) Downregulate Osteosarcoma Cell Migration and Expression of Pro-Inflammatory Cytokines.
Francesconi O, Corzana F, Kontogianni GI, Pesciullesi G, Gualdani R, Supuran CT, Angeli A, Kavasi RM, Chatzinikolaidou M, Nativi C. Francesconi O, et al. Among authors: corzana f. ACS Pharmacol Transl Sci. 2022 Sep 13;5(11):1119-1127. doi: 10.1021/acsptsci.2c00114. eCollection 2022 Nov 11. ACS Pharmacol Transl Sci. 2022. PMID: 36407953 Free PMC article.
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses.
Bermejo IA, Guerreiro A, Eguskiza A, Martínez-Sáez N, Lazaris FS, Asín A, Somovilla VJ, Compañón I, Raju TK, Tadic S, Garrido P, García-Sanmartín J, Mangini V, Grosso AS, Marcelo F, Avenoza A, Busto JH, García-Martín F, Hurtado-Guerrero R, Peregrina JM, Bernardes GJL, Martínez A, Fiammengo R, Corzana F. Bermejo IA, et al. Among authors: corzana f. JACS Au. 2023 Nov 21;4(1):150-163. doi: 10.1021/jacsau.3c00587. eCollection 2024 Jan 22. JACS Au. 2023. PMID: 38274250 Free PMC article.
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.
Mikutis S, Rebelo M, Yankova E, Gu M, Tang C, Coelho AR, Yang M, Hazemi ME, Pires de Miranda M, Eleftheriou M, Robertson M, Vassiliou GS, Adams DJ, Simas JP, Corzana F, Schneekloth JS Jr, Tzelepis K, Bernardes GJL. Mikutis S, et al. Among authors: corzana f. ACS Cent Sci. 2023 Apr 26;9(5):892-904. doi: 10.1021/acscentsci.3c00015. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252343 Free PMC article.
Molecular Recognition of GalNAc in Mucin-Type O-Glycosylation.
Sanz-Martinez I, Pereira S, Merino P, Corzana F, Hurtado-Guerrero R. Sanz-Martinez I, et al. Among authors: corzana f. Acc Chem Res. 2023 Mar 7;56(5):548-560. doi: 10.1021/acs.accounts.2c00723. Epub 2023 Feb 23. Acc Chem Res. 2023. PMID: 36815693 Free PMC article. Review.
A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.
Asensio JL, Hidalgo A, Bastida A, Torrado M, Corzana F, Chiara JL, García-Junceda E, Cañada J, Jiménez-Barbero J. Asensio JL, et al. Among authors: corzana f. J Am Chem Soc. 2005 Jun 15;127(23):8278-9. doi: 10.1021/ja051722z. J Am Chem Soc. 2005. PMID: 15941249 Free article.
146 results