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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT. Rao SPS, et al. Among authors: cortopassi wa. Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29. Science. 2023. PMID: 37384702 Free article.
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues.
Cortopassi WA, Gunderson E, Annunciato Y, Silva AES, Dos Santos Ferreira A, Garcia Teles CB, Pimentel AS, Ramamoorthi R, Gazarini ML, Meneghetti MR, Guido RVC, Pereira DB, Jacobson MP, Krettli AU, Caroline C Aguiar A. Cortopassi WA, et al. Int J Parasitol Drugs Drug Resist. 2022 Dec;20:121-128. doi: 10.1016/j.ijpddr.2022.10.003. Epub 2022 Oct 31. Int J Parasitol Drugs Drug Resist. 2022. PMID: 36375339 Free PMC article.
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, Perell G, Kalra P, Vinh KB, Cortopassi WA, Heitel P, Christensen KE, Cooper RI, Paton RS, Pomerantz WCK, Biggin PC, Hammond EM, Filippakopoulos P, Conway SJ. Brand M, et al. Among authors: cortopassi wa. J Med Chem. 2021 Jul 22;64(14):10102-10123. doi: 10.1021/acs.jmedchem.1c00348. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255515 Free PMC article.
Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.
Tsai WC, Aleem AM, Whittington C, Cortopassi WA, Kalyanaraman C, Baroz A, Iavarone AT, Skrzypczak-Jankun E, Jacobson MP, Offenbacher AR, Holman T. Tsai WC, et al. Among authors: cortopassi wa. Biochemistry. 2021 Mar 16;60(10):802-812. doi: 10.1021/acs.biochem.1c00053. Epub 2021 Feb 26. Biochemistry. 2021. PMID: 33635645
Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium.
Pikman Y, Tasian SK, Sulis ML, Stevenson K, Blonquist TM, Apsel Winger B, Cooper TM, Pauly M, Maloney KW, Burke MJ, Brown PA, Gossai N, McNeer JL, Shukla NN, Cole PD, Kahn JM, Chen J, Barth MJ, Magee JA, Gennarini L, Adhav AA, Clinton CM, Ocasio-Martinez N, Gotti G, Li Y, Lin S, Imamovic A, Tognon CE, Patel T, Faust HL, Contreras CF, Cremer A, Cortopassi WA, Garrido Ruiz D, Jacobson MP, Dharia NV, Su A, Robichaud AL, Saur Conway A, Tarlock K, Stieglitz E, Place AE, Puissant A, Hunger SP, Kim AS, Lindeman NI, Gore L, Janeway KA, Silverman LB, Tyner JW, Harris MH, Loh ML, Stegmaier K. Pikman Y, et al. Among authors: cortopassi wa. Cancer Discov. 2021 Jun;11(6):1424-1439. doi: 10.1158/2159-8290.CD-20-0564. Epub 2021 Feb 9. Cancer Discov. 2021. PMID: 33563661 Free PMC article. Clinical Trial.
Challenges in the Regulation of High-Cost Treatments: An Overview From Brazil.
Pereira LC, Sturzenegger DVR, Ortiz J, Ayad NME, Cortopassi WA, Safatle LP, Khuri N. Pereira LC, et al. Among authors: cortopassi wa. Value Health Reg Issues. 2019 Dec;20:191-195. doi: 10.1016/j.vhri.2019.07.006. Epub 2019 Nov 13. Value Health Reg Issues. 2019. PMID: 31733406 Free article.
31 results