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Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
Vanrusselt H, Kum DB, Taverniti V, Liu C, Acosta Sanchez A, Corthout N, Munck S, Baumert TF, Beigelman L, Blatt LM, Symons JA, Deval J, Raboisson P, Verrier ER, Jekle A, Vendeville S, Debing Y. Vanrusselt H, et al. Among authors: corthout n. J Virol. 2023 Oct 31;97(10):e0072223. doi: 10.1128/jvi.00722-23. Epub 2023 Sep 27. J Virol. 2023. PMID: 37754761 Free PMC article.
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Kum DB, Vanrusselt H, Acosta Sanchez A, Taverniti V, Verrier ER, Baumert TF, Liu C, Deval J, Corthout N, Munck S, Beigelman L, Blatt LM, Symons JA, Raboisson P, Jekle A, Vendeville S, Debing Y. Kum DB, et al. Among authors: corthout n. Hepatology. 2023 Oct 1;78(4):1252-1265. doi: 10.1097/HEP.0000000000000428. Epub 2023 Apr 28. Hepatology. 2023. PMID: 37102495
Mitochondria metabolism sets the species-specific tempo of neuronal development.
Iwata R, Casimir P, Erkol E, Boubakar L, Planque M, Gallego López IM, Ditkowska M, Gaspariunaite V, Beckers S, Remans D, Vints K, Vandekeere A, Poovathingal S, Bird M, Vlaeminck I, Creemers E, Wierda K, Corthout N, Vermeersch P, Carpentier S, Davie K, Mazzone M, Gounko NV, Aerts S, Ghesquière B, Fendt SM, Vanderhaeghen P. Iwata R, et al. Among authors: corthout n. Science. 2023 Feb 10;379(6632):eabn4705. doi: 10.1126/science.abn4705. Epub 2023 Feb 10. Science. 2023. PMID: 36705539
FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms.
Stoklund Dittlau K, Terrie L, Baatsen P, Kerstens A, De Swert L, Janky R, Corthout N, Masrori P, Van Damme P, Hyttel P, Meyer M, Thorrez L, Freude K, Van Den Bosch L. Stoklund Dittlau K, et al. Among authors: corthout n. Mol Neurodegener. 2023 Jan 18;18(1):5. doi: 10.1186/s13024-022-00591-3. Mol Neurodegener. 2023. PMID: 36653804 Free PMC article.
Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction.
Zijlmans DW, Talon I, Verhelst S, Bendall A, Van Nerum K, Javali A, Malcolm AA, van Knippenberg SSFA, Biggins L, To SK, Janiszewski A, Admiraal D, Knops R, Corthout N, Balaton BP, Georgolopoulos G, Panda A, Bhanu NV, Collier AJ, Fabian C, Allsop RN, Chappell J, Pham TXA, Oberhuemer M, Ertekin C, Vanheer L, Athanasouli P, Lluis F, Deforce D, Jansen JH, Garcia BA, Vermeulen M, Rivron N, Dhaenens M, Marks H, Rugg-Gunn PJ, Pasque V. Zijlmans DW, et al. Among authors: corthout n. Nat Cell Biol. 2022 Jun;24(6):858-871. doi: 10.1038/s41556-022-00932-w. Epub 2022 Jun 13. Nat Cell Biol. 2022. PMID: 35697783 Free PMC article.
Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches.
Mesnieres M, Böhm AM, Peredo N, Trompet D, Valle-Tenney R, Bajaj M, Corthout N, Nefyodova E, Cardoen R, Baatsen P, Munck S, Nagy A, Haigh JJ, Khurana S, Verfaillie CM, Maes C. Mesnieres M, et al. Among authors: corthout n. Cell Rep. 2021 Aug 24;36(8):109618. doi: 10.1016/j.celrep.2021.109618. Cell Rep. 2021. PMID: 34433017 Free PMC article.
25 results