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Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency.
Álvarez-Quilón A, Terrón-Bautista J, Delgado-Sainz I, Serrano-Benítez A, Romero-Granados R, Martínez-García PM, Jimeno-González S, Bernal-Lozano C, Quintero C, García-Quintanilla L, Cortés-Ledesma F. Álvarez-Quilón A, et al. Nat Commun. 2020 Feb 14;11(1):910. doi: 10.1038/s41467-020-14638-w. Nat Commun. 2020. PMID: 32060399 Free PMC article.
A Genetic Map of the Response to DNA Damage in Human Cells.
Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortés-Ledesma F, Williams RS, Martin A, Xu D, Durocher D. Olivieri M, et al. Among authors: cortes ledesma f. Cell. 2020 Jul 23;182(2):481-496.e21. doi: 10.1016/j.cell.2020.05.040. Epub 2020 Jul 9. Cell. 2020. PMID: 32649862 Free PMC article.
Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing.
Herrero-Ruiz A, Martínez-García PM, Terrón-Bautista J, Millán-Zambrano G, Lieberman JA, Jimeno-González S, Cortés-Ledesma F. Herrero-Ruiz A, et al. Among authors: cortes ledesma f. Cell Rep. 2021 Apr 13;35(2):108977. doi: 10.1016/j.celrep.2021.108977. Cell Rep. 2021. PMID: 33852840 Free PMC article.
Data of transcriptional effects of the merbarone-mediated inhibition of TOP2.
Delgado-Chaves FM, Martínez-García PM, Herrero-Ruiz A, Gómez-Vela F, Divina F, Jimeno-González S, Cortés-Ledesma F. Delgado-Chaves FM, et al. Among authors: cortes ledesma f. Data Brief. 2022 Aug 1;44:108499. doi: 10.1016/j.dib.2022.108499. eCollection 2022 Oct. Data Brief. 2022. PMID: 35983130 Free PMC article.
Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity.
Terrón-Bautista J, Martínez-Sánchez MDM, López-Hernández L, Vadusevan AA, García-Domínguez M, Williams RS, Aguilera A, Millán-Zambrano G, Cortés-Ledesma F. Terrón-Bautista J, et al. Among authors: cortes ledesma f. bioRxiv [Preprint]. 2024 Jan 23:2024.01.22.576640. doi: 10.1101/2024.01.22.576640. bioRxiv. 2024. PMID: 38328138 Free PMC article. Preprint.
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW. Gómez-Herreros F, et al. Nat Genet. 2014 May;46(5):516-21. doi: 10.1038/ng.2929. Epub 2014 Mar 23. Nat Genet. 2014. PMID: 24658003
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
Feng W, Kawauchi D, Körkel-Qu H, Deng H, Serger E, Sieber L, Lieberman JA, Jimeno-González S, Lambo S, Hanna BS, Harim Y, Jansen M, Neuerburg A, Friesen O, Zuckermann M, Rajendran V, Gronych J, Ayrault O, Korshunov A, Jones DT, Kool M, Northcott PA, Lichter P, Cortés-Ledesma F, Pfister SM, Liu HK. Feng W, et al. Nat Commun. 2017 Mar 20;8:14758. doi: 10.1038/ncomms14758. Nat Commun. 2017. PMID: 28317875 Free PMC article.
36 results