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Uses for humanised mouse models in precision medicine for neurodegenerative disease.
Nair RR, Corrochano S, Gasco S, Tibbit C, Thompson D, Maduro C, Ali Z, Fratta P, Arozena AA, Cunningham TJ, Fisher EMC. Nair RR, et al. Among authors: corrochano s. Mamm Genome. 2019 Aug;30(7-8):173-191. doi: 10.1007/s00335-019-09807-2. Epub 2019 Jun 15. Mamm Genome. 2019. PMID: 31203387 Free PMC article. Review.
Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.
Stewart M, Lau P, Banks G, Bains RS, Castroflorio E, Oliver PL, Dixon CL, Kruer MC, Kullmann DM, Acevedo-Arozena A, Wells SE, Corrochano S, Nolan PM. Stewart M, et al. Among authors: corrochano s. Dis Model Mech. 2019 Feb 22;12(2):dmm036806. doi: 10.1242/dmm.036806. Dis Model Mech. 2019. PMID: 30692144 Free PMC article.
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.
Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, Peden AA, Lichtenberg M, Menzies FM, Ravikumar B, Imarisio S, Brown S, O'Kane CJ, Rubinsztein DC. Winslow AR, et al. Among authors: corrochano s. J Cell Biol. 2010 Sep 20;190(6):1023-37. doi: 10.1083/jcb.201003122. J Cell Biol. 2010. PMID: 20855506 Free PMC article.
α-Synuclein levels modulate Huntington's disease in mice.
Corrochano S, Renna M, Carter S, Chrobot N, Kent R, Stewart M, Cooper J, Brown SD, Rubinsztein DC, Acevedo-Arozena A. Corrochano S, et al. Hum Mol Genet. 2012 Feb 1;21(3):485-94. doi: 10.1093/hmg/ddr477. Epub 2011 Oct 18. Hum Mol Genet. 2012. PMID: 22010050 Free PMC article.
IGF-1 receptor antagonism inhibits autophagy.
Renna M, Bento CF, Fleming A, Menzies FM, Siddiqi FH, Ravikumar B, Puri C, Garcia-Arencibia M, Sadiq O, Corrochano S, Carter S, Brown SD, Acevedo-Arozena A, Rubinsztein DC. Renna M, et al. Among authors: corrochano s. Hum Mol Genet. 2013 Nov 15;22(22):4528-44. doi: 10.1093/hmg/ddt300. Epub 2013 Jun 25. Hum Mol Genet. 2013. PMID: 23804751 Free PMC article.
32 results